KEGG   ENZYME: 1.1.99.33Help
Entry
EC 1.1.99.33                Enzyme                                 
Name
formate dehydrogenase (acceptor);
FDHH;
FDH-H;
FDH-O;
formate dehydrogenase H;
formate dehydrogenase O
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors
BRITE hierarchy
Sysname
formate:acceptor oxidoreductase
Reaction(IUBMB)
formate + acceptor = CO2 + reduced acceptor [RN:R09481]
Reaction(KEGG)
Substrate
formate [CPD:C00058];
acceptor [CPD:C00028]
Product
CO2 [CPD:C00011];
reduced acceptor [CPD:C00030]
Comment
Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1].
Reference
1  [PMID:2211698]
  Authors
Axley MJ, Grahame DA, Stadtman TC
  Title
Escherichia coli formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component.
  Journal
J. Biol. Chem. 265 (1990) 18213-8.
  Organism
Escherichia coli [GN:eco]
Reference
2  [PMID:8626495]
  Authors
Gladyshev VN, Boyington JC, Khangulov SV, Grahame DA, Stadtman TC, Sun PD
  Title
Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis.
  Journal
J. Biol. Chem. 271 (1996) 8095-100.
  Organism
Escherichia coli [GN:eco]
Reference
3  [PMID:9521673]
  Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
  Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
  Journal
Biochemistry. 37 (1998) 3518-28.
  Organism
Escherichia coli [GN:eco]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
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