KEGG   ENZYME: 1.1.99.39Help
Entry
EC 1.1.99.39                Enzyme                                 

Name
D-2-hydroxyglutarate dehydrogenase;
D2HGDH (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R10575]
Reaction(KEGG)
Substrate
(R)-2-hydroxyglutarate [CPD:C01087];
acceptor [CPD:C00028]
Product
2-oxoglutarate [CPD:C00026];
reduced acceptor [CPD:C00030]
Comment
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.
History
EC 1.1.99.39 created 2013
Orthology
K18204  
D-2-hydroxyglutarate dehydrogenase
Genes
HSA: 
728294(D2HGDH)
PTR: 
748707(D2HGDH)
PPS: 
100983509(D2HGDH)
GGO: 
101133731(D2HGDH)
PON: 
NLE: 
100598101(D2HGDH)
MCC: 
702028(D2HGDH)
MCF: 
102118732(D2HGDH)
CSAB: 
103218250(D2HGDH)
RRO: 
104673075(D2HGDH)
CJC: 
100398724(D2HGDH)
SBQ: 
101043256(D2HGDH)
MMU: 
98314(D2hgdh)
RNO: 
301624(D2hgdh)
CGE: 
100773592(D2hgdh)
NGI: 
103730854(D2hgdh)
HGL: 
101721825(D2hgdh)
CCAN: 
109682469(D2hgdh)
OCU: 
100343021(D2HGDH)
TUP: 
102498469(D2HGDH)
CFA: 
609641(D2HGDH)
AML: 
100479601(D2HGDH)
UMR: 
103662596(D2HGDH)
FCA: 
101098076(D2HGDH)
PTG: 
102957898(D2HGDH)
AJU: 
106984596(D2HGDH)
BTA: 
533003(D2HGDH)
BOM: 
102270610(D2HGDH)
BIU: 
109556611(D2HGDH)
PHD: 
102323421(D2HGDH)
CHX: 
OAS: 
101121480(D2HGDH)
CFR: 
102518026(D2HGDH)
BACU: 
103015223(D2HGDH)
LVE: 
103086049(D2HGDH)
ECB: 
100067872(D2HGDH)
MYB: 
102261514(D2HGDH)
MYD: 
102768727(D2HGDH)
HAI: 
109374862(D2HGDH)
RSS: 
109439203(D2HGDH)
PALE: 
102878813(D2HGDH)
LAV: 
100665076(D2HGDH)
MDO: 
100012430(D2HGDH)
SHR: 
100930000(D2HGDH)
OAA: 
100082378(D2HGDH)
GGA: 
424853(D2HGDH)
MGP: 
100542797(D2HGDH)
CJO: 
107317964(D2HGDH)
APLA: 
101797675(D2HGDH)
TGU: 
100218606(D2HGDH)
GFR: 
102043646(D2HGDH)
FAB: 
101812765(D2HGDH)
PHI: 
102103390(D2HGDH)
CCW: 
104696747(D2HGDH)
FCH: 
102048188(ING5)
CLV: 
102096725(D2HGDH)
AAM: 
106492631(D2HGDH)
ASN: 
102385710(ING5)
AMJ: 
102572947(D2HGDH)
PSS: 
102462295(D2HGDH)
CMY: 
102934724(D2HGDH)
CPIC: 
101949760(D2HGDH)
ACS: 
100553833(d2hgdh)
PBI: 
103060731(D2HGDH)
GJA: 
107114547(D2HGDH)
XLA: 
108718159(d2hgdh.S)
XTR: 
100379761(d2hgdh)
DRE: 
565889(d2hgdh)
IPU: 
108267866(d2hgdh)
TRU: 
101062526(d2hgdh)
TNG: 
LCO: 
104926586(d2hgdh)
MZE: 
101466758(d2hgdh)
OLA: 
101158736(d2hgdh)
XMA: 
102225785(d2hgdh)
CSEM: 
103380089(d2hgdh)
SASA: 
LCM: 
102352928(D2HGDH)
CMK: 
103174498(d2hgdh)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
Dmel_CG3835(D2hgdh)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD16587(Dsim_GD16587)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
PBAR: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_F54D5.12(F54D5.12)
CBR: 
NAI: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
AT4G36400(D2HGDH)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj2g3v1728750.1(Lj2g3v1728750.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
ZJU: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0007s13500g(POPTRDRAFT_1083676)
VVI: 
SLY: 
SPEN: 
SOT: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
4342598(D2HGDH)
DOSA: 
Os07t0187200-01(Os07g0187200)
OBR: 
BDI: 
ATS: 
ZMA: 
100273608(si618066c08)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
ACAN: 
TET: 
PTM: 
SMIN: 
v1.2.004695.t1(symbB.v1.2.004695.t1)
PTI: 
FCY: 
TPS: 
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:19586914]
  Authors
Engqvist M, Drincovich MF, Flugge UI, Maurino VG
  Title
Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.
  Journal
J. Biol. Chem. 284 (2009) 25026-37.
  Sequence
[ath:AT4G36400]
Reference
2  [PMID:15070399]
  Authors
Achouri Y, Noel G, Vertommen D, Rider MH, Veiga-Da-Cunha M, Van Schaftingen E
  Title
Identification of a dehydrogenase acting on D-2-hydroxyglutarate.
  Journal
Biochem. J. 381 (2004) 35-42.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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