KEGG   ENZYME: 1.1.99.7Help
Entry
EC 1.1.99.7                 Enzyme                                 

Name
lactate---malate transhydrogenase;
malate-lactate transhydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors
BRITE hierarchy
Sysname
(S)-lactate:oxaloacetate oxidoreductase
Reaction(IUBMB)
(S)-lactate + oxaloacetate = pyruvate + malate [RN:R01447]
Reaction(KEGG)
Substrate
(S)-lactate [CPD:C00186];
oxaloacetate [CPD:C00036]
Product
pyruvate [CPD:C00022];
malate [CPD:C00149]
Comment
Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.
History
EC 1.1.99.7 created 1972
Pathway
Pyruvate metabolism
Metabolic pathways
Reference
1  [PMID:4289051]
  Authors
Allen SH.
  Title
The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus.
  Journal
J. Biol. Chem. 241 (1966) 5266-75.
  Organism
Micrococcus lactilyticus
Reference
2  [PMID:4333516]
  Authors
Allen SH, Patil JR.
  Title
Studies on the structure and mechanism of action of the malate-lactate transhydrogenase.
  Journal
J. Biol. Chem. 247 (1972) 909-16.
  Organism
Micrococcus lactilyticus, Veillonella alcalescens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9077-15-0

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