| Entry |
|
|---|
| Name |
alcohol dehydrogenase (acceptor);
primary alcohol dehydrogenase;
MDH;
quinohemoprotein alcohol dehydrogenase;
quinoprotein alcohol dehydrogenase;
quinoprotein ethanol dehydrogenase;
alcohol:(acceptor) oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors
 |
|---|
| Sysname |
alcohol:acceptor oxidoreductase |
|---|
| Reaction(IUBMB) |
a primary alcohol + acceptor = an aldehyde + reduced acceptor
[RN:R00639] |
|---|
| Reaction(KEGG) |
R00639 > R01146 R05062 R05121 R05198 R05285;
(other) R02479
 |
|---|
| Substrate |
primary alcohol [CPD:C00226];
acceptor [CPD:C00028] |
|---|
| Product |
aldehyde [CPD:C00071];
reduced acceptor [CPD:C00030] |
|---|
| Cofactor |
PQQ [CPD:C00113] |
|---|
| Comment |
A quinoprotein. Acts on a wide range of primary alcohols, including
methanol [cf. EC 1.1.99.20 alkan-1-ol dehydrogenase (acceptor)]. |
|---|
| Pathway |
PATH: ec00010 Glycolysis / Gluconeogenesis
PATH: ec00631 1,2-Dichloroethane degradation
PATH: ec00640 Propanoate metabolism
PATH: ec00650 Butanoate metabolism
PATH: ec00680 Methane metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00114 alcohol dehydrogenase (acceptor) |
|---|
| Genes |
APL: APL_1859
XCC: XCC3479(mxaF) XCC3482(mxaF)
XCB: XC_0679 XC_0682
XCV: XCV0708(mxaF) XCV0709(mxaF)
XAC: XAC0648(mxaF)
PPR: PBPRA2212
PAE: PA1982(exaA)
PPU: PP_2674(qedH) PP_2679
PFL: PFL_2216(exaA) PFL_2221(exaA)
MCA: MCA0299 MCA0779(mxaF) MCA0782(mxaI)
REU: Reut_A1784 Reut_B4160
BXE: Bxe_B2427
VEI: Veis_1826 Veis_1829 Veis_4972
MPT: Mpe_A0341 Mpe_A0476 Mpe_A0877 Mpe_A1591 Mpe_A1595 Mpe_A3393
Mpe_A3660
AZO: azo2844(exaA1) azo2972(exaA2) azo2975(exaA3) azo3022(exaA4)
azo3865(exaA5)
DAR: Daro_1023
MFA: Mfla_0344 Mfla_1717 Mfla_2041
SME: SM_b20173
BJA: bll7639 blr6207(exaA) blr6213(mxaF')
BRA: BRADO0123 BRADO1707 BRADO3897 BRADO5480 BRADO5484(mxaF')
BBT: BBta_2017 BBta_3937 BBta_5964 BBta_5968(mxaF')
RPC: RPC_1907
RPE: RPE_0851 RPE_3136 RPE_3139 RPE_3525
OCA: OCAR_6748
MEX: Mext_1809 Mext_4150
MRD: Mrad2831_0508
MET: M446_5752
MPO: Mpop_1761
MCH: Mchl_2145
SIL: SPO1508
RSP: RSP_2578(xoxF)
RSQ: Rsph17025_1945
RDE: RD1_0890(moxF)
DSH: Dshi_0476(gcd)
HNE: HNE_0129(adhA)
GOX: GOX1068
GBE: GbCGDNIH1_0122 GbCGDNIH1_0344 GbCGDNIH1_0347 GbCGDNIH1_0651
GbCGDNIH1_1922
ACR: Acry_2790
MSM: MSMEG_3726
SEN: SACE_4449(exaA)
RBA: RB12562(adh)
 |
|---|
| Structures |
PDB: 1G72 1H4I 1H4J 1LRW 1W6S 2AD6 2AD7 2AD8 2D0V 4AAH
8ADH |
|---|
Reference
Authors
Title
Journal
|
1
Ameyama, M. and Adachi, O.
Alcohol dehydrogenase from acetic acid bacteria, membrane-bound.
Methods Enzymol. 89 (1982) 450-457. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6058112]
Anthony C, Zatman LJ.
The microbial oxidation of methanol. Purification and properties of
the alcohol dehydrogenase of Pseudomonas sp. M27.
Biochem. J. 104 (1967) 953-9.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:520586]
Duine JA, Frank J, van Zeeland JK.
Glucose dehydrogenase from Acinetobacter calcoaceticus: a
'quinoprotein'.
FEBS. Lett. 108 (1979) 443-6.
Acinetobacter calcoaceticus |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:6250827]
Duine JA, Frank J, Verwiel PE.
Structure and activity of the prosthetic group of methanol
dehydrogenase.
Eur. J. Biochem. 108 (1980) 187-92.
Acinetobacter calcoaceticus |
|---|
Reference
Authors
Title
Journal
|
5 [PMID:471057]
Salisbury SA, Forrest HS, Cruse WB, Kennard O.
A novel coenzyme from bacterial primary alcohol dehydrogenases.
Nature. 280 (1979) 843-4. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.99.8
IUBMB Enzyme Nomenclature: 1.1.99.8
ExPASy - ENZYME nomenclature database: 1.1.99.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.99.8
BRENDA, the Enzyme Database: 1.1.99.8
CAS: 37205-43-9 |
|---|
