KEGG   ENZYME: 1.10.3.11Help
Entry
EC 1.10.3.11                Enzyme                                 

Name
ubiquinol oxidase (non-electrogenic);
plant alternative oxidase;
cyanide-insensitive oxidase;
AOX (gene name);
ubiquinol oxidase
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
ubiquinol:O2 oxidoreductase (non-electrogenic)
Reaction(IUBMB)
2 ubiquinol + O2 = 2 ubiquinone + 2 H2O [RN:R09504]
Reaction(KEGG)
Substrate
ubiquinol [CPD:C00390];
O2 [CPD:C00007]
Product
ubiquinone [CPD:C00399];
H2O [CPD:C00001]
Comment
The enzyme, described from the mitochondria of plants and some fungi and protists, is an alternative terminal oxidase that is not sensitive to cyanide inhibition and does not generate a proton motive force. Unlike the electrogenic terminal oxidases that contain hemes (cf. EC 1.10.3.10 and EC 1.10.3.14), this enzyme contains a dinuclear non-heme iron complex. The function of this oxidase is believed to be dissipating excess reducing power, minimizing oxidative stress, and optimizing photosynthesis in response to changing conditions.
History
EC 1.10.3.11 created 2011, modified 2014
Orthology
K17893  
ubiquinol oxidase
Genes
ATH: 
AT1G32350(AOX1D) AT3G22360(AOX1B) AT3G22370(AOX1A) AT3G27620(AOX1C) AT5G64210(AOX2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
547897(AOX2) 547924(AOX1) 548077(AOX3)
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0003s10290g(POPTRDRAFT_414439) POPTR_0012s01620g(POPTRDRAFT_891190) POPTR_0015s02150g(POPTRDRAFT_732929)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0700400-01(Os02g0700400) Os04t0600200-01(Os04g0600200) Os04t0600300-01(Os04g0600300)
OBR: 
BDI: 
SBI: 
SORBI_04g030820(SORBIDRAFT_04g030820) SORBI_06g027410(SORBIDRAFT_06g027410) SORBI_06g027430(SORBIDRAFT_06g027430)
ZMA: 
100281353 542073(aox1) 542074(aox1)
SITA: 
ATR: 
s00038p00176930(AMTR_s00038p00176930) s00048p00194630(AMTR_s00048p00194630)
SMO: 
PPP: 
CME: 
GSL: 
CCP: 
NGR: 
VCA: 
MBS: 
LLO: 
MEC: 
TKM: 
TBD: 
MEH: 
CSE: 
PZU: 
RDE: 
RLI: 
OAT: 
OAR: 
MMR: 
NAR: 
SWI: 
PEL: 
APB: 
 » show all
Taxonomy
Reference
1  [PMID:16657603]
  Authors
Bendall DS, Bonner WD
  Title
Cyanide-insensitive Respiration in Plant Mitochondria.
  Journal
Plant. Physiol. 47 (1971) 236-45.
Reference
2  [PMID:7698344]
  Authors
Siedow JN, Umbach AL, Moore AL
  Title
The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.
  Journal
FEBS. Lett. 362 (1995) 10-4.
  Organism
Arabidopsis thaliana, Glycine max, Nicotiana tabacum
  Sequence
[ath:AT3G22370] [gmx:547924] [up:Q41224]
Reference
3  [PMID:11106766]
  Authors
Berthold DA, Andersson ME, Nordlund P
  Title
New insight into the structure and function of the alternative oxidase.
  Journal
Biochim. Biophys. Acta. 1460 (2000) 241-54.
Reference
4  [PMID:20169184]
  Authors
Williams BA, Elliot C, Burri L, Kido Y, Kita K, Moore AL, Keeling PJ
  Title
A broad distribution of the alternative oxidase in microsporidian parasites.
  Journal
PLoS. Pathog. 6 (2010) e1000761.
  Organism
Microsporidian parasite
  Sequence
[up:D5JAJ1]
Reference
5  [PMID:22848123]
  Authors
Gandin A, Duffes C, Day DA, Cousins AB
  Title
The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO(2) in Arabidopsis thaliana.
  Journal
Plant. Cell. Physiol. 53 (2012) 1627-37.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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