KEGG   ENZYME: 1.10.3.11Help
Entry
EC 1.10.3.11                Enzyme                                 
Name
ubiquinol oxidase;
plant alternative oxidase;
cyanide-insensitive oxidase;
cytochrome bd-II oxidase
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
ubiquinol:O2 oxidoreductase (non-electrogenic)
Reaction(IUBMB)
2 ubiquinol + O2 = 2 ubiquinone + 2 H2O [RN:R09504]
Reaction(KEGG)
Substrate
ubiquinol [CPD:C00390];
O2 [CPD:C00007]
Product
ubiquinone [CPD:C00399];
H2O [CPD:C00001]
Comment
The enzyme in mitochondria from thermogenic tissues of plants and from certain protists contains a dinuclear iron complex. Cytochrome bd-II from Escherichia coli contains a diheme active site.
Reference
1  [PMID:16657603]
  Authors
Bendall DS, Bonner WD
  Title
Cyanide-insensitive Respiration in Plant Mitochondria.
  Journal
Plant. Physiol. 47 (1971) 236-45.
Reference
2  [PMID:7698344]
  Authors
Siedow JN, Umbach AL, Moore AL
  Title
The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.
  Journal
FEBS. Lett. 362 (1995) 10-4.
Reference
3  [PMID:20169184]
  Authors
Williams BA, Elliot C, Burri L, Kido Y, Kita K, Moore AL, Keeling PJ
  Title
A broad distribution of the alternative oxidase in microsporidian parasites.
  Journal
PLoS. Pathog. 6 (2010) e1000761.
Reference
4  [PMID:20392690]
  Authors
Shepherd M, Sanguinetti G, Cook GM, Poole RK
  Title
Compensations for diminished terminal oxidase activity in Escherichia coli: cytochrome bd-II-mediated respiration and glutamate metabolism.
  Journal
J. Biol. Chem. 285 (2010) 18464-72.
Other DBs
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