KEGG   ENZYME: 1.10.3.4Help
Entry
EC 1.10.3.4                 Enzyme                                 

Name
o-aminophenol oxidase;
isophenoxazine synthase;
o-aminophenol:O2 oxidoreductase;
2-aminophenol:O2 oxidoreductase
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
2-aminophenol:oxygen oxidoreductase
Reaction(IUBMB)
4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O [RN:R00074]
Reaction(KEGG)
R00074;
(other) R08762 R08763
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Substrate
2-aminophenol [CPD:C01987];
O2 [CPD:C00007]
Product
2-aminophenoxazin-3-one [CPD:C02161];
H2O [CPD:C00001]
Comment
A flavoprotein which catalyses a 6-electron oxidation. The enzyme from the plant Tecoma stans requires Mn2+ and FAD [1] whereas the fungus Pycnoporus coccineus requires Mn2+ and riboflavin 5'-phosphate [2], the bacteria Streptomyces antibioticus requires Cu2+ [4] and the plant Bauhenia monandra does not require any co-factors [3].
History
EC 1.10.3.4 created 1972, modified 2006
Pathway
Tryptophan metabolism
Reference
1  [PMID:14170322]
  Authors
NAIR PM, VAIDYANATHAN CS.
  Title
ISOPHENOXAZINE SYNTHASE.
  Journal
Biochim. Biophys. Acta. 81 (1964) 507-16.
Reference
2  [PMID:14298835]
  Authors
NAIR PM, VINING LC.
  Title
ESOPHENOXAZINE SYNTHASE APOENZYME FROM PYCNOPORUS COCCINEUS.
  Journal
Biochim. Biophys. Acta. 96 (1965) 318-27.
Reference
3  [PMID:4166439]
  Authors
Subba Rao PV, Vaidyanathan CS.
  Title
Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.
  Journal
Arch. Biochem. Biophys. 118 (1967) 388-94.
Reference
4  [PMID:2477054]
  Authors
Barry CE 3rd, Nayar PG, Begley TP
  Title
Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin.
  Journal
Biochemistry. 28 (1989) 6323-33.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9013-85-8

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