KEGG   ENZYME: 1.11.1.11Help
Entry
EC 1.11.1.11                Enzyme                                 

Name
L-ascorbate peroxidase;
L-ascorbic acid peroxidase;
L-ascorbic acid-specific peroxidase;
ascorbate peroxidase;
ascorbic acid peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
L-ascorbate:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O (overall reaction) [RN:R00644];
(1a) 2 L-ascorbate + H2O2 + 2 H+ = 2 monodehydroascorbate + 2 H2O [RN:R09540];
(1b) 2 monodehydroascorbate = L-ascorbate + L-dehydroascorbate (spontaneous) [RN:R03186]
Reaction(KEGG)
Substrate
L-ascorbate [CPD:C00072];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
monodehydroascorbate [CPD:C01041]
Product
L-ascorbate [CPD:C00072];
L-dehydroascorbate [CPD:C05422];
H2O [CPD:C00001];
monodehydroascorbate [CPD:C01041]
Comment
A heme protein. Oxidizes ascorbate and low molecular weight aromatic substrates. The monodehydroascorbate radical produced is either directly reduced back to ascorbate by EC 1.6.5.4 [monodehydroascorbate reductase (NADH)] or undergoes non-enzymic disproportionation to ascorbate and dehydroascorbate.
History
EC 1.11.1.11 created 1983, modified 2010, modified 2011
Pathway
Ascorbate and aldarate metabolism
Glutathione metabolism
Orthology
K00434  
L-ascorbate peroxidase
Genes
ATH: 
AT1G07890(APX1) AT1G77490(TAPX) AT3G09640(APX2) AT4G08390(SAPX) AT4G09010(APX4) AT4G32320(APX6) AT4G35000(APX3) AT4G35970(APX5)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0002s08240g(POPTRDRAFT_798682) POPTR_0004s18030g(POPTRDRAFT_831312) POPTR_0005s11430g POPTR_0005s17350g(POPTRDRAFT_864655) POPTR_0005s20140g(POPTRDRAFT_209946) POPTR_0006s08980g(POPTRDRAFT_560799) POPTR_0006s13440g POPTR_0006s27060g(POPTRDRAFT_819605) POPTR_0009s02070g(POPTRDRAFT_821619) POPTR_0009s13650g(POPTRDRAFT_557084) POPTR_0016s08580g(POPTRDRAFT_1103794)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0553200-01(Os02g0553200) Os03t0285700-01(Os03g0285700) Os04t0223300-00(Os04g0223300) Os04t0434800-01(Os04g0434800) Os04t0602100-01(Os04g0602100) Os07t0694700-01(Os07g0694700) Os08t0522400-01(Os08g0522400) Os08t0549100-01(Os08g0549100) Os12t0178100-01(Os12g0178100) Os12t0178200-01(Os12g0178200)
OBR: 
BDI: 
SBI: 
SORBI_01g038760(SORBIDRAFT_01g038760) SORBI_02g044060(SORBIDRAFT_02g044060) SORBI_04g022560(SORBIDRAFT_04g022560) SORBI_06g001970(SORBIDRAFT_06g001970) SORBI_06g017080(SORBIDRAFT_06g017080) SORBI_07g024880(SORBIDRAFT_07g024880) SORBI_07g027300(SORBIDRAFT_07g027300) SORBI_08g004880(SORBIDRAFT_08g004880)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00017p00249040(AMTR_s00017p00249040) s00023p00249630(AMTR_s00023p00249630) s00048p00223020(AMTR_s00048p00223020) s00055p00061980(AMTR_s00055p00061980) s00078p00035540(AMTR_s00078p00035540)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
VAL: 
PTE: 
ZTR: 
PFJ: 
MBR: 
PTI: 
TPS: 
EHX: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
 » show all
Taxonomy
Reference
1  [PMID:6772104]
  Authors
Shigeoka S, Nakano Y, Kitaoka S.
  Title
Purification and some properties of L-ascorbic-acid-specific peroxidase in Euglena gracilis Z.
  Journal
Arch. Biochem. Biophys. 201 (1980) 121-7.
Reference
2  [PMID:6768357]
  Authors
Shigeoka S, Nakano Y, Kitaoka S.
  Title
Metabolism of hydrogen peroxide in Euglena gracilis Z by L-ascorbic acid peroxidase.
  Journal
Biochem. J. 186 (1980) 377-80.
Reference
3
  Authors
Nakano, Y and Asada, K.
  Title
Purification of ascorbate peroxidase in spinach chloroplasts; its inactivation in ascorbate-depleted medium and reactivation by monodehydroascorbate radical.
  Journal
Plant Cell Physiol. 28 (1987) 131-140.
Reference
4  [PMID:7703247]
  Authors
Patterson WR, Poulos TL
  Title
Crystal structure of recombinant pea cytosolic ascorbate peroxidase.
  Journal
Biochemistry. 34 (1995) 4331-41.
  Sequence
[up:P48534]
Reference
5  [PMID:15236572]
  Authors
Sharp KH, Moody PC, Brown KA, Raven EL
  Title
Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.
  Journal
Biochemistry. 43 (2004) 8644-51.
  Sequence
[gmx:553156]
Reference
6  [PMID:16784232]
  Authors
Macdonald IK, Badyal SK, Ghamsari L, Moody PC, Raven EL
  Title
Interaction of ascorbate peroxidase with substrates: a mechanistic and structural analysis.
  Journal
Biochemistry. 45 (2006) 7808-17.
  Sequence
[gmx:553156]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
72906-87-7

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