KEGG   ENZYME: 1.11.1.12Help
Entry
EC 1.11.1.12                Enzyme                                 

Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O [RN:R03167]
Reaction(KEGG)
Substrate
glutathione [CPD:C00051];
lipid hydroperoxide [CPD:C01025]
Product
glutathione disulfide [CPD:C00127];
lipid [CPD:C01356];
H2O [CPD:C00001]
Comment
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptor; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).
History
EC 1.11.1.12 created 1989
Pathway
Glutathione metabolism
Orthology
K05361  
phospholipid-hydroperoxide glutathione peroxidase
Genes
HSA: 
2879(GPX4)
PTR: 
741876(GPX4)
PPS: 
100990361(GPX4)
GGO: 
101140897(GPX4)
PON: 
100458624(GPX4)
NLE: 
100601223(GPX4)
MCC: 
705333(GPX4)
MCF: 
102142580(GPX4)
CJC: 
MMU: 
625249(Gpx4)
RNO: 
29328(Gpx4)
CGE: 
100765235(Gpx4)
NGI: 
103737339(Gpx4)
HGL: 
101708875(Gpx4)
TUP: 
102483947(GPX4)
UMR: 
103681777(GPX4)
FCA: 
PTG: 
102949955(GPX4)
BTA: 
286809(GPX4)
BOM: 
102284111(GPX4)
PHD: 
102324249(GPX4)
CHX: 
100860867(GPX4)
OAS: 
101113149(GPX4)
SSC: 
399537(GPX4)
CFR: 
102515650(GPX4)
BACU: 
103000913(GPX4)
LVE: 
103071491(GPX4)
MYB: 
102257806(GPX4)
MYD: 
102758267(GPX4)
PALE: 
102878189(GPX4)
MDO: 
100015749(GPX4)
SHR: 
100930158(GPX4)
OAA: 
100088643(GPX4)
MGP: 
100379155(GPX4)
APLA: 
101796330(GPX4)
TGU: 
FAB: 
101817765(GPX4)
PHI: 
102113402(GPX4)
FPG: 
101916317(GPX4)
FCH: 
102055857(GPX4)
CLV: 
102092188(GPX4)
ASN: 
102386897(GPX4)
AMJ: 
102570581(GPX4)
PSS: 
102460999(GPX4)
CMY: 
102948400(GPX4)
ACS: 
100563257(gpx4)
PBI: 
103065827(GPX4)
XLA: 
100036920(gpx4-a) 734888(gpx4-b)
XTR: 
100145414(gpx4) 100496541(gpx4)
DRE: 
352928(gpx4a) 352929(gpx4b)
OLA: 
CMK: 
103189927(gpx4)
BFO: 
TCA: 
ISC: 
TSP: 
LGI: 
 » show all
Taxonomy
Reference
1  [PMID:3978121]
  Authors
Ursini F, Maiorino M, Gregolin C.
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
  Journal
Biochim. Biophys. Acta. 839 (1985) 62-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-70-8

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