KEGG   ENZYME: 1.11.1.12Help
Entry
EC 1.11.1.12                Enzyme                                 
Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O [RN:R03167]
Reaction(KEGG)
Substrate
glutathione [CPD:C00051];
lipid hydroperoxide [CPD:C01025]
Product
glutathione disulfide [CPD:C00127];
lipid [CPD:C01356];
H2O [CPD:C00001]
Comment
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptor; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).
Pathway
Glutathione metabolism
Orthology
K05361  
phospholipid-hydroperoxide glutathione peroxidase
Genes
HSA: 
2879(GPX4)
PTR: 
741876(GPX4)
PPS: 
100990361(GPX4)
GGO: 
101140897(GPX4)
PON: 
100458624(GPX4)
MCC: 
705333(GPX4)
MMU: 
625249(Gpx4)
RNO: 
29328(Gpx4)
FCA: 
101095956(GPX4)
BTA: 
286809(GPX4)
SSC: 
399537(GPX4)
MDO: 
100015749
SHR: 
100930158(GPX4)
OAA: 
100088643
MGP: 
100379155(GPX4)
TGU: 
100190423
ACS: 
100563257
XLA: 
100036920(gpx4-a) 734888(gpx4-b)
XTR: 
100145414(gpx4)
DRE: 
352928(gpx4a) 352929(gpx4b)
OLA: 
101160762
TET: 
TTHERM_00046090 TTHERM_00046110 TTHERM_00895630 TTHERM_00895640 TTHERM_01099010
 » show all
Taxonomy
Reference
1  [PMID:3978121]
  Authors
Ursini F, Maiorino M, Gregolin C.
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
  Journal
Biochim. Biophys. Acta. 839 (1985) 62-70.
  Organism
Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-70-8
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