KEGG   ENZYME: 1.11.1.13Help
Entry
EC 1.11.1.13                Enzyme                                 

Name
manganese peroxidase;
peroxidase-M2;
Mn-dependent (NADH-oxidizing) peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
Mn(II):hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O [RN:R00011]
Reaction(KEGG)
Substrate
Mn(II) [CPD:C19610];
H+ [CPD:C00080];
H2O2 [CPD:C00027]
Product
Mn(III) [CPD:C19611];
H2O [CPD:C00001]
Comment
A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ [4]. The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates [1]. It is inactive with veratryl alcohol or nonphenolic substrates.
History
EC 1.11.1.13 created 1992
Orthology
K20205  
manganese peroxidase
Genes
PXB: 
MTM: 
TMN: 
NHE: 
MAW: 
MAJ: 
VAL: 
VDA: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
BCOM: 
NPA: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
LBC: 
MRR: 
CCI: 
ABP: 
AGABI1DRAFT71350(AGABI1DRAFT_71350) AGABI1DRAFT80178(AGABI1DRAFT_80178)
ABV: 
AGABI2DRAFT188334(AGABI2DRAFT_188334) AGABI2DRAFT221245(MnP)
 » show all
Taxonomy
Reference
1  [PMID:3800395]
  Authors
Glenn JK, Akileswaran L, Gold MH.
  Title
Mn(II) oxidation is the principal function of the extracellular Mn-peroxidase from Phanerochaete chrysosporium.
  Journal
Arch. Biochem. Biophys. 251 (1986) 688-96.
Reference
2  [PMID:3080953]
  Authors
Paszczynski A, Huynh VB, Crawford R.
  Title
Comparison of ligninase-I and peroxidase-M2 from the white-rot fungus Phanerochaete chrysosporium.
  Journal
Arch. Biochem. Biophys. 244 (1986) 750-65.
Reference
3  [PMID:3167051]
  Authors
Wariishi H, Akileswaran L, Gold MH.
  Title
Manganese peroxidase from the basidiomycete Phanerochaete chrysosporium: spectral characterization of the oxidized states and the catalytic cycle.
  Journal
Biochemistry. 27 (1988) 5365-70.
Reference
4  [PMID:8433984]
  Authors
Kuan IC, Tien M
  Title
Stimulation of Mn peroxidase activity: a possible role for oxalate in lignin biodegradation.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 1242-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
114995-15-2

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