| Entry |
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| Name |
lignin peroxidase;
diarylpropane oxygenase;
ligninase I;
diarylpropane peroxidase;
LiP;
diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)
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| Class |
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
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| Sysname |
1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase
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| Reaction(IUBMB) |
(3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O [RN: R04461]
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| Reaction(KEGG) |
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| Substrate |
(3,4-dimethoxyphenyl)methanol;
H2O2 [CPD: C00027]
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| Product |
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| Comment |
A hemoprotein, involved in the oxidative breakdown of lignin by white-rot basidiomycete fungi. The enzyme from Phanerochaete chrysosporium oxidizes typical peroxidase dye substrates at the heme iron, a reaction involving the formation of Compound II (FeIV=O); it also oxidizes (3,4-dimethoxyphenyl)methanol (veratryl alcohol) to the radical cation. The bound veratryl alcohol radical is proposed to bring about the oxidative cleavage of C-C and ether (C-O-C) bonds in lignin model compounds of the diarylpropane and arylpropane-aryl ether type.
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| Reference |
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| Authors |
Kersten PJ, Tien M, Kalyanaraman B, Kirk TK. |
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| Title |
The ligninase of Phanerochaete chrysosporium generates cation radicals from methoxybenzenes. |
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| Journal |
J. Biol. Chem. 260 (1985) 2609-12. |
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| Organism |
Phanerochaete chrysosporium |
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| Reference |
|
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| Authors |
Paszczynski A, Huynh VB, Crawford R. |
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| Title |
Comparison of ligninase-I and peroxidase-M2 from the white-rot fungus Phanerochaete chrysosporium. |
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| Journal |
Arch. Biochem. Biophys. 244 (1986) 750-65. |
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| Organism |
Phanerochaete chrysosporium |
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| Reference |
3 |
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| Authors |
Harvey, P.J., Schoemaker, H.E. and Palmer, J.M. |
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| Title |
Veratryl alcohol as a mediator and the role of radical cations in lignin biodegradation by Phanerochaete chrysosporium. |
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| Journal |
FEBS Lett. 195 (1986) 242-246. |
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| Reference |
|
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| Authors |
Doyle WA, Blodig W, Veitch NC, Piontek K, Smith AT. |
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| Title |
Two substrate interaction sites in lignin peroxidase revealed by site-directed mutagenesis. |
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| Journal |
Biochemistry. 37 (1998) 15097-105. |
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| Organism |
Phanerochaete chrysosporium |
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| Reference |
|
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| Authors |
Wariishi H, Marquez L, Dunford HB, Gold MH. |
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| Title |
Lignin peroxidase compounds II and III. Spectral and kinetic characterization of reactions with peroxides. |
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| Journal |
J. Biol. Chem. 265 (1990) 11137-42. |
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| Organism |
Phanerochaete chrysosporium |
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| Reference |
|
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| Authors |
Cai DY, Tien M. |
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| Title |
Characterization of the oxycomplex of lignin peroxidases from Phanerochaete chrysosporium: equilibrium and kinetics studies. |
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| Journal |
Biochemistry. 29 (1990) 2085-91. |
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| Organism |
Phanerochaete chrysosporium |
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| Reference |
|
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| Authors |
Khindaria A, Yamazaki I, Aust SD |
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| Title |
Veratryl alcohol oxidation by lignin peroxidase. |
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| Journal |
Biochemistry. 34 (1995) 16860-9. |
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| Reference |
|
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| Authors |
Khindaria A, Yamazaki I, Aust SD |
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| Title |
Stabilization of the veratryl alcohol cation radical by lignin peroxidase. |
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| Journal |
Biochemistry. 35 (1996) 6418-24. |
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| Reference |
|
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| Authors |
Khindaria A, Nie G, Aust SD |
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| Title |
Detection and characterization of the lignin peroxidase compound II-veratryl alcohol cation radical complex. |
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| Journal |
Biochemistry. 36 (1997) 14181-5. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 93792-13-3 |
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