KEGG   ENZYME: 1.11.1.18Help
Entry
EC 1.11.1.18                Enzyme                                 

Name
bromide peroxidase;
bromoperoxidase;
haloperoxidase (ambiguous);
eosinophil peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
bromide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
RH + HBr + H2O2 = RBr + 2 H2O [RN:R09505]
Reaction(KEGG)
Substrate
RH [CPD:C01371];
HBr [CPD:C13645];
H2O2 [CPD:C00027]
Product
RBr [CPD:C00720];
H2O [CPD:C00001]
Comment
Bromoperoxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. They catalyse the bromination of a range of organic molecules such as sesquiterpenes, forming stable C-Br bonds. Bromoperoxidases also oxidize iodides.
History
EC 1.11.1.18 created 2010
Reference
1
  Authors
De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R
  Title
Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina.
  Journal
Biochim. Biophys. Acta 872 (1986) 104-115.
Reference
2  [PMID:2400770]
  Authors
Tromp MG, Olafsson G, Krenn BE, Wever R
  Title
Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum.
  Journal
Biochim. Biophys. Acta. 1040 (1990) 192-8.
  Organism
Ascophyllum nodosum
Reference
3  [PMID:10843856]
  Authors
Isupov MN, Dalby AR, Brindley AA, Izumi Y, Tanabe T, Murshudov GN, Littlechild JA
  Title
Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red  algae Corallina officinalis.
  Journal
J. Mol. Biol. 299 (2000) 1035-49.
  Organism
Corallina officinalis
  Sequence
[up:Q8LLW7]
Reference
4  [PMID:15548002]
  Authors
Carter-Franklin JN, Butler A
  Title
Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products.
  Journal
J. Am. Chem. Soc. 126 (2004) 15060-6.
  Organism
Corallina officinalis, Laurencia pacifica, Plocamium cartilagineum
Reference
5  [PMID:15133166]
  Authors
Ohshiro T, Littlechild J, Garcia-Rodriguez E, Isupov MN, Iida Y, Kobayashi T, Izumi Y
  Title
Modification of halogen specificity of a vanadium-dependent bromoperoxidase.
  Journal
Protein. Sci. 13 (2004) 1566-71.
  Organism
Corallina pilulifera
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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