KEGG   ENZYME: 1.11.1.19Help
Entry
EC 1.11.1.19                Enzyme                                 

Name
dye decolorizing peroxidase;
DyP;
DyP-type peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
Reactive-Blue-5:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
Reactive Blue 5 + 2 H2O2 = phthalate + 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H2O [RN:R10915]
Reaction(KEGG)
Substrate
Reactive Blue 5 [CPD:C19693];
H2O2 [CPD:C00027]
Product
phthalate [CPD:C01606];
2,2'-disulfonyl azobenzene [CPD:C20938];
3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate [CPD:C20939];
H2O [CPD:C00001]
Comment
Heme proteins with proximal histidine secreted by basidiomycetous fungi and eubacteria. They are similar to EC 1.11.1.16 versatile peroxidase (oxidation of Reactive Black 5, phenols, veratryl alcohol), but differ from the latter in their ability to efficiently oxidize a number of recalcitrant anthraquinone dyes, and inability to oxidize Mn(II). The model substrate Reactive Blue 5 is converted with high efficiency via a so far unique mechanism that combines oxidative and hydrolytic steps and leads to the formation of phthalic acid. Bacterial TfuDyP catalyses sulfoxidation.
History
EC 1.11.1.19 created 2011, modified 2015
Orthology
K15733  
dye decolorizing peroxidase
Genes
MSM: 
MSG: 
MSB: 
MSN: 
MSH: 
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MMV: 
MAY: 
MABO: 
MABL: 
MAZ: 
MAK: 
MYS: 
MYC: 
MCHE: 
MIZ: 
MMC: 
MKM: 
MJL: 
MNE: 
MYV: 
MGO: 
MFT: 
MPHL: 
MVQ: 
CGL: 
NCgl1608(Cgl1672)
CGB: 
CGU: 
CGT: 
CGS: 
CGG: 
CGM: 
CGJ: 
CGQ: 
CGX: 
CEF: 
CDI: 
CDP: 
CDH: 
CDT: 
CDE: 
CDR: 
CDA: 
CDZ: 
CDB: 
CDS: 
CDD: 
CDW: 
CDV: 
CDIP: 
CJK: 
CUR: 
CUA: 
CAR: 
CKP: 
CPU: 
CPL: 
CPG: 
CPP: 
CPK: 
CPQ: 
CPX: 
CPZ: 
COR: 
COP: 
COD: 
COS: 
COI: 
COE: 
COU: 
CPSE: 
CPSU: 
CPSF: 
CRD: 
CUL: 
CUC: 
CUE: 
CUN: 
CUS: 
CUQ: 
CUZ: 
CUJ: 
CVA: 
CHN: 
CCN: 
CTER: 
CMD: 
CAZ: 
CFN: 
CCG: 
CVT: 
CGY: 
CII: 
COA: 
CDO: 
CHM: 
CSX: 
CMQ: 
CKU: 
CCJ: 
CMV: 
CEI: 
CTED: 
CUT: 
CLW: 
CDX: 
CSP: 
CSTA: 
CCJZ: 
CFK: 
BFV: 
NFA: 
NFR: 
NCY: 
NBR: 
NNO: 
NSL: 
NSR: 
RER: 
REY: 
REB: 
ROP: 
REQ: 
RPY: 
RHB: 
RAV: 
RHW: 
GOQ: 
DTM: 
SCO: 
SCO3963(SCD78.30c)
SMA: 
SGR: 
SGB: 
SCB: 
SSX: 
SVL: 
SCT: 
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
SALS: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRM: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
STRF: 
SLE: 
sle_36660(sle_36660) sle_58700(sle_58700)
SRN: 
SPAV: 
SLC: 
STRT: 
SCLF: 
SGS: 
STSI: 
SLS: 
SNR: 
SPLU: 
STRD: 
SNW: 
KSK: 
LXX: 
LXY: 
MTS: 
MIO: 
MIX: 
MIP: 
RLA: 
RPLA: 
MVD: 
AGY: 
ARM: 
ARI: 
ARL: 
AAQ: 
ARY: 
AAI: 
GAR: 
KRH: 
KPL: 
KFV: 
MLU: 
RDN: 
NAE: 
BFA: 
BRX: 
BRV: 
DVA: 
JDE: 
KSE: 
IDO: 
I598_0264(efeN)
SKE: 
ICA: 
ARS: 
BLY: 
BLIN: 
TFL: 
TEZ: 
NCA: 
NDK: 
I601_3704(efeN_2)
KFL: 
PSIM: 
AER: 
TFU: 
NDA: 
NAL: 
TCU: 
SRO: 
NOA: 
FRA: 
FAL: 
NML: 
SVI: 
SESP: 
KAL: 
AHM: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
AMS: 
ACTN: 
L083_3539(efeB)
AFS: 
CAI: 
SNA: 
MCU: 
 » show all
Taxonomy
Reference
1  [PMID:10049859]
  Authors
Kim SJ, Shoda M
  Title
Purification and characterization of a novel peroxidase from Geotrichum candidum  dec 1 involved in decolorization of dyes.
  Journal
Appl. Environ. Microbiol. 65 (1999) 1029-35.
Reference
2  [PMID:15313183]
  Authors
Sugano Y, Ishii Y, Shoda M
  Title
Role of H164 in a unique dye-decolorizing heme peroxidase DyP.
  Journal
Biochem. Biophys. Res. Commun. 322 (2004) 126-32.
Reference
3  [PMID:17654547]
  Authors
Zubieta C, Joseph R, Krishna SS, McMullan D, Kapoor M, Axelrod HL, Miller MD, Abdubek P, Acosta C, Astakhova T, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, Elias Y, Elsliger MA, Feuerhelm J, Grzechnik SK, Hale J, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Kumar A, Marciano D, Morse AT, Murphy KD, Nigoghossian E, Okach L, Oommachen S, Reyes R, Rife CL, Schimmel P, Trout CV, van den Bedem H, Weekes D, White A, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA
  Title
Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA.
  Journal
Proteins. 69 (2007) 234-43.
Reference
4  [PMID:19009358]
  Authors
Sugano Y, Matsushima Y, Tsuchiya K, Aoki H, Hirai M, Shoda M
  Title
Degradation pathway of an anthraquinone dye catalyzed by a unique peroxidase DyP  from Thanatephorus cucumeris Dec 1.
  Journal
Biodegradation. 20 (2009) 433-40.
Reference
5  [PMID:19099183]
  Authors
Sugano Y
  Title
DyP-type peroxidases comprise a novel heme peroxidase family.
  Journal
Cell. Mol. Life. Sci. 66 (2009) 1387-403.
Reference
6  [PMID:19801472]
  Authors
Ogola HJ, Kamiike T, Hashimoto N, Ashida H, Ishikawa T, Shibata H, Sawa Y
  Title
Molecular characterization of a novel peroxidase from the cyanobacterium Anabaena sp. strain PCC 7120.
  Journal
Appl. Environ. Microbiol. 75 (2009) 7509-18.
Reference
7  [PMID:19967355]
  Authors
van Bloois E, Torres Pazmino DE, Winter RT, Fraaije MW
  Title
A robust and extracellular heme-containing peroxidase from Thermobifida fusca as  prototype of a bacterial peroxidase superfamily.
  Journal
Appl. Microbiol. Biotechnol. 86 (2010) 1419-30.
  Sequence
[tfu:Tfu_3078]
Reference
8  [PMID:19756587]
  Authors
Liers C, Bobeth C, Pecyna M, Ullrich R, Hofrichter M
  Title
DyP-like peroxidases of the jelly fungus Auricularia auricula-judae oxidize nonphenolic lignin model compounds and high-redox potential dyes.
  Journal
Appl. Microbiol. Biotechnol. 85 (2010) 1869-79.
Reference
9  [PMID:20495915]
  Authors
Hofrichter M, Ullrich R, Pecyna MJ, Liers C, Lundell T
  Title
New and classic families of secreted fungal heme peroxidases.
  Journal
Appl. Microbiol. Biotechnol. 87 (2010) 871-97.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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