KEGG   ENZYME: 1.11.1.20Help
Entry
EC 1.11.1.20                Enzyme                                 

Name
prostamide/prostaglandin F2alpha synthase;
prostamide/PGF synthase;
prostamide F synthase;
prostamide/prostaglandin F synthase;
tPGF synthase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase
Reaction(IUBMB)
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [RN:R09506]
Reaction(KEGG)
Substrate
thioredoxin [CPD:C00342];
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate [CPD:C00427]
Product
thioredoxin disulfide [CPD:C00343];
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [CPD:C00639]
Comment
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
History
EC 1.11.1.20 created 2011
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K15717  
prostamide/prostaglandin F2alpha synthase
Genes
HSA: 
127281(FAM213B)
PTR: 
744202(FAM213B)
PPS: 
100989393(FAM213B)
GGO: 
101134253(FAM213B)
PON: 
100190803(FAM213B)
NLE: 
100586906(FAM213B)
MCC: 
695160(FAM213B)
MCF: 
102136927(FAM213B)
RRO: 
104664581(FAM213B)
CJC: 
100403434(FAM213B)
MMU: 
66469(Fam213b)
RNO: 
362676(Fam213b)
CGE: 
100755514(Fam213b)
NGI: 
103749778(Fam213b)
HGL: 
101722975(Fam213b)
TUP: 
102487629(FAM213B)
CFA: 
489616(FAM213B)
AML: 
100476330(FAM213B)
UMR: 
103678433(FAM213B)
FCA: 
101090122(FAM213B)
PTG: 
102951174(FAM213B)
BTA: 
617001(FAM213B)
BOM: 
102268856(FAM213B)
PHD: 
CHX: 
102184926(FAM213B)
OAS: 
101120767(FAM213B)
SSC: 
100134955(FAM213B)
CFR: 
102509927(FAM213B)
BACU: 
103000861(FAM213B)
LVE: 
103071802(FAM213B)
ECB: 
100054405(FAM213B)
PALE: 
102887804(FAM213B)
MDO: 
100027973(FAM213B)
SHR: 
100932106(FAM213B)
ASN: 
102371358(FAM213B)
AMJ: 
102569997(FAM213B)
PSS: 
102455880(FAM213B)
CMY: 
102948080(FAM213B)
GJA: 
107110400(FAM213B)
XLA: 
447017(fam213b)
XTR: 
549974(fam213b)
DRE: 
406605(fam213b)
TRU: 
101064795(fam213b)
MZE: 
101467269(fam213b)
OLA: 
101173382(fam213b)
XMA: 
102226891(fam213b)
LCM: 
102361632(FAM213B)
BFO: 
CIN: 
SPU: 
BMOR: 
PXY: 
LGI: 
CRG: 
SMM: 
NVE: 
HMG: 
AQU: 
PPP: 
GSL: 
AAF: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:18006499]
  Authors
Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K
  Title
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.
  Journal
J. Biol. Chem. 283 (2008) 792-801.
  Sequence
[ssc:100134955]
Reference
2  [PMID:20950588]
  Authors
Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
  Title
Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.
  Journal
Brain. Res. 1367 (2011) 22-32.
  Sequence
[mmu:66469]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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