KEGG   ENZYME: 1.11.1.22Help
Entry
EC 1.11.1.22                Enzyme                                 

Name
hydroperoxy fatty acid reductase;
slr1171 (gene name);
slr1992 (gene name);
hydroperoxy fatty acid:NADPH oxidoreductase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
NADPH:hydroperoxy fatty acid oxidoreductase
Reaction(IUBMB)
a hydroperoxy fatty acid + NADPH + H+ = a hydroxy fatty acid + NADP+ + H2O
Substrate
hydroperoxy fatty acid;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
hydroxy fatty acid;
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the cyanobacterium Synechocystis PCC 6803, can reduce unsaturated fatty acid hydroperoxides and alkyl hydroperoxides. The enzyme, which utilizes NADPH generated by the photosynthetic electron transfer system, protects the cells from lipid peroxidation.
History
EC 1.11.1.22 created 2013
Orthology
K20207  
hydroperoxy fatty acid reductase
Genes
SYN: 
SYZ: 
SYY: 
SYNGTS_1305(slr1992) SYNGTS_1769(slr1171)
SYT: 
SYNGTI_1305(slr1992) SYNGTI_1769(slr1171)
SYS: 
SYNPCCN_1304(slr1992) SYNPCCN_1768(slr1171)
SYQ: 
SYNPCCP_1304(slr1992) SYNPCCP_1768(slr1171)
SYJ: 
SYP: 
LEP: 
Taxonomy
Reference
1  [PMID:11418106]
  Authors
Gaber A, Tamoi M, Takeda T, Nakano Y, Shigeoka S
  Title
NADPH-dependent glutathione peroxidase-like proteins (Gpx-1, Gpx-2) reduce unsaturated fatty acid hydroperoxides in Synechocystis PCC 6803.
  Journal
FEBS. Lett. 499 (2001) 32-6.
  Sequence
Reference
2  [PMID:15347790]
  Authors
Gaber A, Yoshimura K, Tamoi M, Takeda T, Nakano Y, Shigeoka S
  Title
Induction and functional analysis of two reduced nicotinamide adenine dinucleotide phosphate-dependent glutathione peroxidase-like proteins in Synechocystis PCC 6803 during the progression of oxidative stress.
  Journal
Plant. Physiol. 136 (2004) 2855-61.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system