KEGG   ENZYME: 1.11.1.8Help
Entry
EC 1.11.1.8                 Enzyme                                 

Name
iodide peroxidase;
thyroid peroxidase;
iodotyrosine deiodase;
iodinase;
iodoperoxidase (heme type);
iodide peroxidase-tyrosine iodinase;
iodotyrosine deiodinase;
monoiodotyrosine deiodinase;
thyroperoxidase;
tyrosine iodinase;
TPO
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
iodide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810];
(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;
(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;
(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08523];
(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08522]
Reaction(KEGG)
Substrate
iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
[thyroglobulin]-L-tyrosine [CPD:C16733];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731]
Product
diiodine [CPD:C01382];
H2O [CPD:C00001];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731];
[thyroglobulin]-L-thyroxine [CPD:C16729];
[thyroglobulin]-aminoacrylate [CPD:C16734];
[thyroglobulin]-3,5,3'-triiodo-L-thyronine [CPD:C16730]
Comment
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
History
EC 1.11.1.8 created 1961, modified 2012
Pathway
Tyrosine metabolism
Metabolic pathways
Orthology
K00431  
thyroid peroxidase
Genes
HSA: 
7173(TPO)
PTR: 
470287(TPO)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
721610(TPO)
MCF: 
CJC: 
MMU: 
22018(Tpo)
RNO: 
54314(Tpo)
CGE: 
HGL: 
TUP: 
CFA: 
403521(TPO)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
525013(TPO)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
776120(TPO)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XTR: 
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
 » show all
Taxonomy
Reference
1  [PMID:13718859]
  Authors
CUNNINGHAM BA, KIRKWOOD S.
  Title
Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.
  Journal
J. Biol. Chem. 236 (1961) 485-9.
Reference
2  [PMID:13964156]
  Authors
HOSOYA T, KONDO Y, UI N.
  Title
Peroxidase activity in thyroid gland and partial purification of the enzyme.
  Journal
J. Biochem. 52 (1962) 180-9.
Reference
3  [PMID:12325367]
  Authors
Coval ML, Taurog A.
  Title
Purification and iodinating activity of hog thyroid peroxidase.
  Journal
J. Biol. Chem. 242 (1967) 5510-23.
Reference
4  [PMID:7021557]
  Authors
Gavaret JM, Cahnmann HJ, Nunez J
  Title
Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.
  Journal
J. Biol. Chem. 256 (1981) 9167-73.
Reference
5  [PMID:7142155]
  Authors
Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I
  Title
One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.
  Journal
J. Biol. Chem. 257 (1982) 13398-403.
Reference
6  [PMID:6706930]
  Authors
Magnusson RP, Taurog A, Dorris ML
  Title
Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.
  Journal
J. Biol. Chem. 259 (1984) 197-205.
Reference
7  [PMID:2996435]
  Authors
Virion A, Courtin F, Deme D, Michot JL, Kaniewski J, Pommier J
  Title
Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.
  Journal
Arch. Biochem. Biophys. 242 (1985) 41-7.
Reference
8  [PMID:1497352]
  Authors
Rawitch AB, Pollock G, Yang SX, Taurog A
  Title
Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.
  Journal
Arch. Biochem. Biophys. 297 (1992) 321-7.
  Sequence
Reference
9  [PMID:8448141]
  Authors
Sun W, Dunford HB
  Title
Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.
  Journal
Biochemistry. 32 (1993) 1324-31.
Reference
10 [PMID:8651700]
  Authors
Taurog A, Dorris ML, Doerge DR
  Title
Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.
  Journal
Arch. Biochem. Biophys. 330 (1996) 24-32.
Reference
11 [PMID:16098474]
  Authors
Ruf J, Carayon P
  Title
Structural and functional aspects of thyroid peroxidase.
  Journal
Arch. Biochem. Biophys. 445 (2006) 269-77.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-28-1

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