KEGG   ENZYME: 1.11.2.1Help
Entry
EC 1.11.2.1                 Enzyme                                 

Name
unspecific peroxygenase;
aromatic peroxygenase;
mushroom peroxygenase;
haloperoxidase-peroxygenase;
Agrocybe aegerita peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
BRITE hierarchy
Sysname
substrate:hydrogen-peroxide oxidoreductase (RH-hydroxylating or -epoxidising)
Reaction(IUBMB)
RH + H2O2 = ROH + H2O [RN:R09507]
Reaction(KEGG)
Substrate
RH [CPD:C01371];
H2O2 [CPD:C00027]
Product
ROH [CPD:C01335];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. They catalyse the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. Reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. They have little or no activity toward chloride. Mechanistically, the catalytic cycle of unspecific (mono)-peroxygenases combines elements of the "shunt" pathway of cytochrome P-450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.
History
EC 1.11.2.1 created 2011
Orthology
K21820  
unspecific peroxygenase
Genes
ADL: 
LBC: 
CCI: 
ABP: 
AGABI1DRAFT111702(AGABI1DRAFT_111702) AGABI1DRAFT111721(AGABI1DRAFT_111721) AGABI1DRAFT111729(AGABI1DRAFT_111729) AGABI1DRAFT111731(AGABI1DRAFT_111731) AGABI1DRAFT111734(AGABI1DRAFT_111734) AGABI1DRAFT111735(AGABI1DRAFT_111735) AGABI1DRAFT111738(AGABI1DRAFT_111738) AGABI1DRAFT113735(AGABI1DRAFT_113735) AGABI1DRAFT114754(AGABI1DRAFT_114754) AGABI1DRAFT115045(AGABI1DRAFT_115045) AGABI1DRAFT115049(AGABI1DRAFT_115049) AGABI1DRAFT115479(AGABI1DRAFT_115479) AGABI1DRAFT118546(AGABI1DRAFT_118546) AGABI1DRAFT118596(AGABI1DRAFT_118596) AGABI1DRAFT121696(AGABI1DRAFT_121696) AGABI1DRAFT121894(AGABI1DRAFT_121894) AGABI1DRAFT122208(AGABI1DRAFT_122208) AGABI1DRAFT134005(AGABI1DRAFT_134005) AGABI1DRAFT30296(AGABI1DRAFT_30296) AGABI1DRAFT76879(AGABI1DRAFT_76879) AGABI1DRAFT76887(AGABI1DRAFT_76887) AGABI1DRAFT78772(AGABI1DRAFT_78772) AGABI1DRAFT88344(AGABI1DRAFT_88344)
ABV: 
AGABI2DRAFT134420(AGABI2DRAFT_134420) AGABI2DRAFT139842(AGABI2DRAFT_139842) AGABI2DRAFT179594(AGABI2DRAFT_179594) AGABI2DRAFT183665(AGABI2DRAFT_183665) AGABI2DRAFT183721(AGABI2DRAFT_183721) AGABI2DRAFT183842(AGABI2DRAFT_183842) AGABI2DRAFT186833(AGABI2DRAFT_186833) AGABI2DRAFT188448(AGABI2DRAFT_188448) AGABI2DRAFT188774(AGABI2DRAFT_188774) AGABI2DRAFT190943(AGABI2DRAFT_190943) AGABI2DRAFT190967(AGABI2DRAFT_190967) AGABI2DRAFT190973(AGABI2DRAFT_190973) AGABI2DRAFT190977(AGABI2DRAFT_190977) AGABI2DRAFT190980(AGABI2DRAFT_190980) AGABI2DRAFT190985(AGABI2DRAFT_190985) AGABI2DRAFT193563(AGABI2DRAFT_193563) AGABI2DRAFT195432(AGABI2DRAFT_195432) AGABI2DRAFT195436(AGABI2DRAFT_195436) AGABI2DRAFT207786(AGABI2DRAFT_207786) AGABI2DRAFT226793(AGABI2DRAFT_226793) AGABI2DRAFT64972(AGABI2DRAFT_64972) AGABI2DRAFT65123(AGABI2DRAFT_65123)
Taxonomy
Reference
1  [PMID:15294788]
  Authors
Ullrich R, Nuske J, Scheibner K, Spantzel J, Hofrichter M
  Title
Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes.
  Journal
Appl. Environ. Microbiol. 70 (2004) 4575-81.
  Sequence
Reference
2  [PMID:16253244]
  Authors
Ullrich R, Hofrichter M
  Title
The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene.
  Journal
FEBS. Lett. 579 (2005) 6247-50.
  Sequence
Reference
3  [PMID:17601809]
  Authors
Anh DH, Ullrich R, Benndorf D, Svatos A, Muck A, Hofrichter M
  Title
The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation.
  Journal
Appl. Environ. Microbiol. 73 (2007) 5477-85.
Reference
4  [PMID:19022254]
  Authors
Ullrich R, Dolge C, Kluge M, Hofrichter M
  Title
Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.
  Journal
FEBS. Lett. 582 (2008) 4100-6.
  Sequence
Reference
5  [PMID:19039585]
  Authors
Aranda E, Kinne M, Kluge M, Ullrich R, Hofrichter M
  Title
Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases.
  Journal
Appl. Microbiol. Biotechnol. 82 (2009) 1057-66.
Reference
6  [PMID:19394224]
  Authors
Kinne M, Poraj-Kobielska M, Aranda E, Ullrich R, Hammel KE, Scheibner K, Hofrichter M
  Title
Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with  a fungal peroxygenase.
  Journal
Bioorg. Med. Chem. Lett. 19 (2009) 3085-7.
  Sequence
Reference
7  [PMID:18815784]
  Authors
Kluge M, Ullrich R, Dolge C, Scheibner K, Hofrichter M
  Title
Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation.
  Journal
Appl. Microbiol. Biotechnol. 81 (2009) 1071-6.
  Sequence
Reference
8  [PMID:19713216]
  Authors
Kinne M, Poraj-Kobielska M, Ralph SA, Ullrich R, Hofrichter M, Hammel KE
  Title
Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase.
  Journal
J. Biol. Chem. 284 (2009) 29343-9.
Reference
9  [PMID:19434406]
  Authors
Pecyna MJ, Ullrich R, Bittner B, Clemens A, Scheibner K, Schubert R, Hofrichter M
  Title
Molecular characterization of aromatic peroxygenase from Agrocybe aegerita.
  Journal
Appl. Microbiol. Biotechnol. 84 (2009) 885-97.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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