KEGG   ENZYME: 1.12.1.5Help
Entry
EC 1.12.1.5                 Enzyme                                 

Name
hydrogen dehydrogenase [NAD(P)+];
hydrogenase II (ambiguous)
Class
Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
hydrogen:NAD(P)+ oxidoreductase
Reaction(IUBMB)
H2 + NAD(P)+ = H+ + NAD(P)H [RN:R00700 R07181]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
H+ [CPD:C00080];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).
History
EC 1.12.1.5 created 2013
Orthology
K17993  
sulfhydrogenase subunit alpha
K17994  
sulfhydrogenase subunit delta
Genes
PHO: 
PH1292(PH1292) PH1294(PH1294)
PAB: 
PAB0640(hydD-2) PAB0641(hydA-2) PAB1786 PAB1787
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
KCR: 
 » show all
Taxonomy
Reference
1  [PMID:10714990]
  Authors
Ma K, Weiss R, Adams MW
  Title
Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.
  Journal
J. Bacteriol. 182 (2000) 1864-71.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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