KEGG   ENZYME: 1.12.2.1Help
Entry
EC 1.12.2.1                 Enzyme                                 
Name
cytochrome-c3 hydrogenase;
H2:ferricytochrome c3 oxidoreductase;
cytochrome c3 reductase;
cytochrome hydrogenase;
hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
hydrogen:ferricytochrome-c3 oxidoreductase
Reaction(IUBMB)
2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3 [RN:R04015]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
ferricytochrome c3 [CPD:C02682]
Product
H+ [CPD:C00080];
ferrocytochrome c3 [CPD:C02684]
Comment
An iron-sulfur protein. Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced.
Orthology
K00437  
cytochrome-c3 hydrogenase
Genes
MCA: 
AZO: 
azo1414(hoxY)
DAR: 
PAB: 
PAB0638(hydB-2) PAB0640(hydD-2) PAB1784
Taxonomy
Reference
1  [PMID:4364940]
  Authors
Der Vartanian DV, LeGall J.
  Title
A monomolecular electron transfer chain: structure and function of cytochrome C3.
  Journal
Biochim. Biophys. Acta. 346 (1974) 79-99.
  Organism
Desulfovibrio desulfuricans [GN:dde], Desulfovibrio gigas, Desulfovibrio vulgaris
Reference
2  [PMID:3546297]
  Authors
Higuchi Y, Yasuoka N, Kakudo M, Katsube Y, Yagi T, Inokuchi H.
  Title
Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F.
  Journal
J. Biol. Chem. 262 (1987) 2823-5.
  Organism
Desulfovibrio vulgaris [GN:dvm]
Reference
3  [PMID:13741672]
  Authors
RIKLIS E, RITTENBERG D.
  Title
Some observations on the enzyme, hydrogenase.
  Journal
J. Biol. Chem. 236 (1961) 2526-9.
  Organism
Desulfovibrio desulfuricans [GN:dde]
Reference
4  [PMID:13745271]
  Authors
SADANA JC, MOREY AV.
  Title
Purification and properties of the hydrogenase of Desulfovibrio desulfuricans.
  Journal
Biochim. Biophys. Acta. 50 (1961) 153-63.
  Organism
Desulfovibrio desulfuricans [GN:dde]
Reference
5  [PMID:7854413]
  Authors
Volbeda A, Charon MH, Piras C, Hatchikian EC, Frey M, Fontecilla-Camps JC.
  Title
Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas.
  Journal
Nature. 373 (1995) 580-7.
  Organism
Desulfovibrio gigas
Reference
6  [PMID:10378275]
  Authors
Garcin E, Vernede X, Hatchikian EC, Volbeda A, Frey M, Fontecilla-Camps JC.
  Title
The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center.
  Journal
Structure. 7 (1999) 557-66.
  Organism
Desulfovibrio gigas
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9027-05-8
DBGET integrated database retrieval system