KEGG   ENZYME: 1.12.5.1Help
Entry
EC 1.12.5.1                 Enzyme                                 

Name
hydrogen:quinone oxidoreductase;
hydrogen-ubiquinone oxidoreductase;
hydrogen:menaquinone oxidoreductase;
membrane-bound hydrogenase;
quinone-reactive Ni/Fe-hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
hydrogen:quinone oxidoreductase
Reaction(IUBMB)
H2 + menaquinone = menaquinol [RN:R02965]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
menaquinone [CPD:C00828]
Product
menaquinol [CPD:C05819]
Comment
Contains nickel, iron-sulfur clusters and cytochrome b. Also catalyses the reduction of water-soluble quinones (e.g. 2,3-dimethylnaphthoquinone) or viologen dyes (benzyl viologen or methyl viologen).
History
EC 1.12.5.1 created 1999 as EC 1.12.99.3, transferred 2002 to EC 1.12.5.1
Orthology
K05922  
quinone-reactive Ni/Fe-hydrogenase large subunit
K05927  
quinone-reactive Ni/Fe-hydrogenase small subunit
Genes
SON: 
SO_2098(hyaB) SO_2099(hyaA)
SFR: 
SAZ: 
SBL: 
SBM: 
SBN: 
SBP: 
SBT: 
SBS: 
SBB: 
SLO: 
SPC: 
SHP: 
SSE: 
SPL: 
SHE: 
SHM: 
SHN: 
SHW: 
SHL: 
SWP: 
FBL: 
TCX: 
HPY: 
HEO: 
HPJ: 
jhp_0574(hyaA) jhp_0575(hyaB)
HPA: 
HPS: 
HHP: 
HHQ: 
HHR: 
HPG: 
HPG27_592(hydA) HPG27_593(hydB)
HPP: 
HPB: 
HPL: 
HPB8_831(hydA) HPB8_832(hydB)
HPC: 
HCA: 
HPM: 
HPE: 
HPO: 
HPI: 
HPQ: 
HPW: 
HPU: 
HEF: 
HPF: 
HEQ: 
HEX: 
HPT: 
HPZ: 
HPKB_0711(hyaB) HPKB_0712(hyaA)
HPV: 
HPX: 
HEN: 
HPH: 
HEG: 
HPN: 
HEP: 
HEU: 
HES: 
HPYS: 
HCN: 
HPD: 
KHP_0688(hydB) KHP_0689(hyaA)
HEY: 
HER: 
HEI: 
HPYA: 
HPYK: 
HPYO: 
HPYL: 
HPYB: 
HPYC: 
HPYD: 
HPYE: 
HPYF: 
HPYG: 
HPYH: 
HPYJ: 
HPYR: 
HPYI: 
HPYU: 
HPYM: 
HEM: 
HEB: 
HEZ: 
HHE: 
HH_0056(hyaA) HH_0057(hyaB) HH_0198
HAC: 
Hac_0744(hyaA) Hac_0745(hyaB)
HMS: 
HMU06120(hydA2) HMU09900(hydB) HMU09910(hydA)
HFE: 
HBI: 
HCE: 
HCM: 
HCP: 
HCB: 
HHM: 
HTY: 
WSU: 
TDN: 
SUA: 
SKU: 
SULR: 
CJE: 
Cj1266c(hydB) Cj1267c(hydA) Cj1399c(hydA2)
CJB: 
CJJ: 
CJU: 
C8J_1210(hydB) C8J_1211(hydA) C8J_1313(hydA2)
CJN: 
CJI: 
CJSA_1205(hydB) CJSA_1206(hydA) CJSA_1330(hydA2)
CJM: 
CJM1_1247(hydB) CJM1_1248(hydA) CJM1_1356(hydA2)
CJS: 
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJV: 
CJY: 
QZ67_01345(hydB) QZ67_01346(hydA_2) QZ67_01533(hydA_3) QZ67_01534(hydA_4)
CJQ: 
UC78_1217(hydB) UC78_1218(hydA_1) UC78_1341(hydA_2)
CJL: 
CJW: 
CJR: 
CJE1402(hydB) CJE1403(hydA) CJE1586
CJD: 
CJZ: 
CJX: 
CFF: 
CFT: 
CFV: 
CFX: 
CFZ: 
CAMP: 
CFP: 
CCV: 
CHA: 
CCO: 
CLA: 
Cla_0414(hydA) Cla_0712(hyaA) Cla_0713(hyaB)
CLR: 
CLM: 
CLQ: 
CLN: 
CLL: 
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
VC76_02990(hydA_2) VC76_02995(hydB) VC76_07000(hydA_3)
CAJ: 
CIS: 
CINS_0691(hydA) CINS_0692(hydB)
CVO: 
CPEL: 
CAMR: 
CSM: 
CSF: 
CGRA: 
CURE: 
ABU: 
Abu_1427(hydB) Abu_1428(hydA) Abu_1434(hyaB) Abu_1435(hyaA)
ABT: 
ABL: 
A7H1H_1448(hydB) A7H1H_1449(hydA) A7H1H_1453(hyaB) A7H1H_1454(hyaA)
ANT: 
ARC: 
SDL: 
SBA: 
SMUL: 
SMUL_1423(hydA) SMUL_1424(hydB)
NSA: 
NIS: 
SUN: 
NAM: 
DAK: 
HMR: 
DAV: 
SAY: 
SAP: 
SAF: 
PMX: 
DIN: 
 » show all
Taxonomy
Reference
1  [PMID:1587288]
  Authors
Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchene A, Tripier D, Juvenal K, et al.
  Title
The quinone-reactive Ni/Fe-hydrogenase of Wolinella succinogenes.
  Journal
Eur. J. Biochem. 206 (1992) 93-102.
  Sequence
Reference
2  [PMID:8319698]
  Authors
Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchene A, Tripier D, Juvenal K, et al.
  Title
The quinone-reactive Ni/Fe-hydrogenase of Wolinella Succinogenes.
  Journal
Eur. J. Biochem. 214 (1993) 949-50.
  Sequence
Reference
3  [PMID:9822828]
  Authors
Gross R, Simon J, Lancaster CR, Kroger A.
  Title
Identification of histidine residues in Wolinella succinogenes hydrogenase that are essential for menaquinone reduction by H2.
  Journal
Mol. Microbiol. 30 (1998) 639-46.
Reference
4  [PMID:9310376]
  Authors
Bernhard M, Benelli B, Hochkoeppler A, Zannoni D, Friedrich B.
  Title
Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16.
  Journal
Eur. J. Biochem. 248 (1997) 179-86.
Reference
5  [PMID:8354459]
  Authors
Ferber DM, Maier RJ.
  Title
Hydrogen-ubiquinone oxidoreductase activity by the Bradyrhizobium japonicum membrane-bound hydrogenase.
  Journal
FEMS. Microbiol. Lett. 110 (1993) 257-64.
Reference
6
  Authors
Ishii, M., Omori, T., Igarashi, Y., Adachi, O., Ameyama, M. and Kodama, T.
  Title
Methionaquinone is a direct natural electron-acceptor for the membrane-bound hydrogenase in Hydrogenobacter thermophilus strain TK-6.
  Journal
Agric. Biol. Chem. 55 (1991) 3011-3016.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
151616-65-8

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