KEGG   ENZYME: 1.12.7.2Help
Entry
EC 1.12.7.2                 Enzyme                                 

Name
ferredoxin hydrogenase;
H2 oxidizing hydrogenase;
H2 producing hydrogenase [ambiguous];
bidirectional hydrogenase;
hydrogen-lyase [ambiguous];
hydrogenase (ferredoxin);
hydrogenase I;
hydrogenase II;
hydrogenlyase [ambiguous];
uptake hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
hydrogen:ferredoxin oxidoreductase
Reaction(IUBMB)
H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+ [RN:R00019]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
oxidized ferredoxin [CPD:C00139]
Product
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.
History
EC 1.12.7.2 created 1961 as EC 1.98.1.1, transferred 1965 to EC 1.12.1.1, transferred 1972 to EC 1.12.7.1, transferred 1978 to EC 1.18.3.1, transferred 1984 to EC 1.18.99.1, transferred 2002 to EC 1.12.7.2
Orthology
K00532  
ferredoxin hydrogenase
K00533  
ferredoxin hydrogenase large subunit
K00534  
ferredoxin hydrogenase small subunit
K06441  
ferredoxin hydrogenase gamma subunit
K18016  
membrane-bound hydrogenase subunit alpha
K18017  
membrane-bound hydrogenase subunit beta
K18023  
membrane-bound hydrogenase subunit mbhJ
Genes
SON: 
SO_3920(hydA) SO_3921(hydB)
SHE: 
SHN: 
SHL: 
FBL: 
LHK: 
LHK_02328(hydC)
RFR: 
PNA: 
MPT: 
DAR: 
PCA: 
Pcar_2502(hndD-1)
DVU: 
DVU1769(hydA) DVU1770(hydB) DVU1771(hydC) DVU2525(hynB-2) DVU2526(hynA-2)
DVL: 
DVG: 
DDE: 
DDS: 
DMA: 
DSA: 
DAS: 
DHY: 
DPS: 
DAT: 
HRM2_26580(hydA2)
DTI: 
SFU: 
BJA: 
bll6944(hupU)
BRA: 
BRADO1682(hupU)
BBT: 
BBta_1994(hupU)
RPA: 
RPA0134(hydC) RPA0959(hupU)
RPE: 
RPT: 
RPX: 
RSP: 
RSP_0492(hupU)
RSH: 
RRU: 
CPR: 
CTC: 
CNO: 
CTH: 
CBE: 
CPY: 
CDF: 
SWO: 
SLP: 
EEL: 
ERE: 
MTA: 
TNR: 
NTH: 
HOR: 
SRI: 
DTE: 
TYE: 
TID: 
MHU: 
MLA: 
MPI: 
PHO: 
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TGAM_0036(mbhL) TGAM_0037(mbhK) TGAM_0038(mbhJ)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
ABI: 
ACF: 
 » show all
Taxonomy
Reference
1
  Authors
Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
  Title
The role of molybdenum and flavin in hydrogenase.
  Journal
J. Am. Chem. Soc. 76 (1954) 3355-3356.
Reference
2
  Authors
Tagawa, K. and Arnon, D.I.
  Title
Ferredoxin as electron carriers in photosynthesis and in the bioogical production and consumption of hydrogen gas.
  Journal
Nature (Lond.) 195 (1962) 537-543.
Reference
3
  Authors
Valentine, R.C., Mortenson, L.E. and Carnahan, J.E.
  Title
The hydrogenase system of Clostridium pasteurianum.
  Journal
J. Biol. Chem. 238 (1963) 1141-1144.
Reference
4  [PMID:164247]
  Authors
Zumft WG, Mortenson LE.
  Title
The nitrogen-fixing complex of bacteria.
  Journal
Biochim. Biophys. Acta. 416 (1975) 1-52.
  Organism
Clostridium pasteurianum [GN:cpas]
Reference
5  [PMID:2173950]
  Authors
Adams MW.
  Title
The structure and mechanism of iron-hydrogenases.
  Journal
Biochim. Biophys. Acta. 1020 (1990) 115-45.
  Organism
Desulfovibrio vulgaris, Clostridium pasteurianum, Megasphaera elsdenii
Reference
6  [PMID:9836629]
  Authors
Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC.
  Title
X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution.
  Journal
Science. 282 (1998) 1853-8.
  Organism
Clostridium pasteurianum [GN:cpas]
  Sequence
[up:P29166]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9027-05-8

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