KEGG   ENZYME: 1.12.98.3Help
Entry
EC 1.12.98.3                Enzyme                                 

Name
Methanosarcina-phenazine hydrogenase;
methanophenazine hydrogenase;
methylviologen-reducing hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase
Reaction(IUBMB)
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine [RN:R09095]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
2-(2,3-dihydropentaprenyloxy)phenazine [CPD:C11903]
Product
2-dihydropentaprenyloxyphenazine
Comment
Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.
History
EC 1.12.98.3 created 2002
Orthology
K14068  
methanophenazine hydrogenase, large subunit
K14069  
methanophenazine hydrogenase, cytochrome b subunit
K14070  
methanophenazine hydrogenase
K22158  
F420H2 dehydrogenase subunit A
K22159  
F420H2 dehydrogenase subunit B
K22160  
F420H2 dehydrogenase subunit C
K22161  
F420H2 dehydrogenase subunit D
K22162  
F420H2 dehydrogenase subunit F
K22163  
F420H2 dehydrogenase subunit H
K22164  
F420H2 dehydrogenase subunit I
K22165  
F420H2 dehydrogenase subunit J
K22166  
F420H2 dehydrogenase subunit K
K22167  
F420H2 dehydrogenase subunit L
K22168  
F420H2 dehydrogenase subunit M
K22169  
F420H2 dehydrogenase subunit N
K22170  
F420H2 dehydrogenase subunit O
Genes
MIG: 
MAC: 
MA_1141(vhtG) MA_1142(vhtA) MA_1143(vhtC) MA_1146(vhtG) MA_1147(vhtA) MA_1148(vhtC) MA_1495(fpoA) MA_1496(fpoB) MA_1497(fpoC) MA_1498(fpoD) MA_1499(fpoH) MA_1500(fpoI) MA_1501(fpoJ) MA_1502(fpoJ) MA_1503(fpoK) MA_1504(fpoL) MA_1505(fpoM) MA_1506(fpoN) MA_1507(fpoO) MA_3732(fpoF)
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MM_0627 MM_2169(vhtG) MM_2170(vhtA) MM_2171(vhtC) MM_2175 MM_2176 MM_2177 MM_2312(vhoC) MM_2313(vhoA) MM_2314(vhoG) MM_2479(fpoO) MM_2480(fpoN) MM_2481(fpoM) MM_2482(fpoL) MM_2483(fpoK) MM_2484(fpoJ) MM_2485(fpoJ) MM_2486(fpoI) MM_2487(fpoH) MM_2488(fpoD) MM_2489(fpoC) MM_2490(fpoB) MM_2491(fpoA)
MMAZ: 
MMJ: 
MMAC: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MHAZ: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_2389(fpoO) MCON_3060(fpoA) MCON_3061(fpoB) MCON_3062(fpoD) MCON_3063(fpoH) MCON_3064 MCON_3067(fpoK) MCON_3068(fpoL) MCON_3069(fpoM) MCON_3070(fpoN)
MHI: 
MFO: 
MPD: 
MCP_2934(vhtG) MCP_2935(vhtA) MCP_2936(vhtC)
MEZ: 
Mtc_0470(vhtG) Mtc_0471(vhtA) Mtc_0472(vhtC)
RCI: 
RCIX880(vhtG) RCIX882(vhtA) RCIX885(vhtC)
AST: 
GAC: 
GAH: 
FAC: 
FAI: 
CDIV: 
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
TCB: 
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
NCT: 
NMSP_1424(fpoN)
CSY: 
NGA: 
NVN: 
NEV: 
TAA: 
NBV: 
TAH: 
NDV: 
NDEV_1820(nuoN)
 » show all
Taxonomy
Reference
1  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J. Bacteriol. 180 (1998) 2027-32.
Reference
2  [PMID:10471795]
  Authors
Deppenmeier U, Lienard T, Gottschalk G.
  Title
Novel reactions involved in energy conservation by methanogenic archaea.
  Journal
FEBS. Lett. 457 (1999) 291-7.
Reference
3  [PMID:10941105]
  Authors
Beifuss U, Tietze M, Baumer S, Deppenmeier U.
  Title
Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie. We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals.
  Journal
Angew. Chem. Int. Ed. Engl. 39 (2000) 2470-2472.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-05-8

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