KEGG   ENZYME: 1.12.98.3Help
Entry
EC 1.12.98.3                Enzyme                                 

Name
Methanosarcina-phenazine hydrogenase;
methanophenazine hydrogenase;
methylviologen-reducing hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase
Reaction(IUBMB)
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine [RN:R09095]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
2-(2,3-dihydropentaprenyloxy)phenazine [CPD:C11903]
Product
2-dihydropentaprenyloxyphenazine
Comment
Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.
History
EC 1.12.98.3 created 2002
Reference
1  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J. Bacteriol. 180 (1998) 2027-32.
Reference
2  [PMID:10471795]
  Authors
Deppenmeier U, Lienard T, Gottschalk G.
  Title
Novel reactions involved in energy conservation by methanogenic archaea.
  Journal
FEBS. Lett. 457 (1999) 291-7.
Reference
3  [PMID:10941105]
  Authors
Beifuss U, Tietze M, Baumer S, Deppenmeier U.
  Title
Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie. We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals.
  Journal
Angew. Chem. Int. Ed. Engl. 39 (2000) 2470-2472.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-05-8

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