KEGG   ENZYME: 1.12.98.4Help
Entry
EC 1.12.98.4                Enzyme                                 

Name
sulfhydrogenase;
sulfur reductase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
H2:polysulfide oxidoreductase
Reaction(IUBMB)
H2 + (sulfide)n = hydrogen sulfide + (sulfide)n-1 [RN:R10390]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
(sulfide)n [CPD:C19692]
Product
hydrogen sulfide [CPD:C00283];
(sulfide)n-1
Comment
An iron-sulfur protein. The enzyme from the hyperthermophilic archaeon Pyrococcus furiosus is part of two heterotetrameric complexes where the beta and gamma subunits function as sulfur reductase and the alpha and delta subunits function as hydrogenases (EC 1.12.1.3, hydrogen dehydrogenase [NADP+] and EC 1.12.1.4, hydrogen dehydrogenase [NAD(P)+], respectively). Sulfur can also be used as substrate, but since it is insoluble in aqueous solution and polysulfide is generated abiotically by the reaction of hydrogen sulfide and sulfur, polysulfide is believed to be the true substrate [2].
History
EC 1.12.98.4 created 1992 as EC 1.97.1.3, transferred 2013 to EC 1.12.98.4
Pathway
Sulfur metabolism
Orthology
K17995  
sulfhydrogenase subunit gamma (sulfur reductase)
K17996  
sulfhydrogenase subunit beta (sulfur reductase)
Genes
PHO: 
PH1290(PH1290) PH1291(PH1291)
PAB: 
PAB0638(hydB-2) PAB0639(hydG-2) PAB1784 PAB1785
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
KCR: 
 » show all
Taxonomy
Reference
1
  Authors
Zophel, A., Kennedy, M.C., Beinert, H. and Kroneck, P.M.H.
  Title
Investigations on microbial sulfur respiration. 1. Activation and reduction of elemental sulfur in several strains of Eubacteria.
  Journal
Arch. Microbiol. 150 (1988) 72-77.
Reference
2  [PMID:8389482]
  Authors
Ma K, Schicho RN, Kelly RM, Adams MW
  Title
Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 5341-4.
  Sequence
Reference
3
  Authors
Ma, K., Zhou, Z.H. and Adams, M.W.
  Title
Hydrogen production from pyruvate by enzymes purified from the hyperthermophilic archaeon, Pyrococcus furiosus: A key role for NADPH.
  Journal
FEMS Microbiol. Lett. 122 (1994) 245-250.
Reference
4  [PMID:10714990]
  Authors
Ma K, Weiss R, Adams MW
  Title
Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.
  Journal
J. Bacteriol. 182 (2000) 1864-71.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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