KEGG   ENZYME: 1.13.11.10Help
Entry
EC 1.13.11.10               Enzyme                                 

Name
7,8-dihydroxykynurenate 8,8a-dioxygenase;
7,8-dihydroxykynurenate oxygenase;
7,8-dihydroxykynurenate 8,8alpha-dioxygenase;
7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (ring-opening)
Reaction(IUBMB)
7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate [RN:R03253]
Reaction(KEGG)
Substrate
7,8-dihydroxykynurenate [CPD:C01111];
O2 [CPD:C00007]
Product
5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate [CPD:C05641]
Comment
Requires Fe2+.
History
EC 1.13.11.10 created 1965 as EC 1.13.1.10, transferred 1972 to EC 1.13.11.10
Pathway
Tryptophan metabolism
Reference
1
  Authors
Kuno, S., Tashiro, M., Taniuchi, H., Horibata, K., Hayaishi, O., Seno, S., Tokuyama, T. and Sakan, T.
  Title
Enzymatic degradation of kynurenic acid.
  Journal
Fed. Proc. 20 (1961) 3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-58-7

DBGET integrated database retrieval system