KEGG   ENZYME: 1.13.11.16Help
Entry
EC 1.13.11.16               Enzyme                                 

Name
3-carboxyethylcatechol 2,3-dioxygenase;
2,3-dihydroxy-beta-phenylpropionic dioxygenase;
2,3-dihydroxy-beta-phenylpropionate oxygenase;
3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase;
3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
(1) 3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate [RN:R04376];
(2) (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate [RN:R06788]
Reaction(KEGG)
Substrate
3-(2,3-dihydroxyphenyl)propanoate [CPD:C04044];
O2 [CPD:C00007];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Product
(2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate [CPD:C04479];
(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate [CPD:C12624]
Comment
An iron protein. This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
History
EC 1.13.11.16 created 1972, modified 2011, modified 2012
Pathway
Phenylalanine metabolism
Microbial metabolism in diverse environments
Orthology
K05713  
2,3-dihydroxyphenylpropionate 1,2-dioxygenase
Genes
ECO: 
b0348(mhpB)
ECJ: 
JW0339(mhpB)
ECD: 
ECOK: 
ECE: 
Z0446(mhpB)
ECS: 
ECs0403(mhpB)
ECF: 
ETW: 
ECSP_0412(mhpB)
ELX: 
EOJ: 
EOI: 
EOH: 
EOK: 
ELR: 
ECX: 
ECW: 
ECM: 
ECY: 
ECR: 
ECQ: 
ECK: 
ECT: 
EOC: 
CE10_0316(mhpB)
EUM: 
ELO: 
ELH: 
ESE: 
ESO: 
O3O_05560(mhpB)
ESM: 
O3M_19720(mhpB)
ESL: 
O3K_19735(mhpB)
ECL: 
EBR: 
ECB_00302(mhpB)
EBD: 
EKO: 
EKF: 
EDH: 
EDJ: 
ENA: 
EUN: 
ELW: 
ECW_m0426(mhpB)
ELL: 
WFL_02095(mhpB)
ELP: 
EBL: 
ECD_00302(mhpB)
EBE: 
B21_00306(mhpB)
ECOA: 
ECOL: 
ECOJ: 
ECOO: 
ECOH: 
ECOS: 
SSN: 
SSON_0295(mhpB)
SSJ: 
SHQ: 
KPN: 
KPN_02121(mhpB)
KPU: 
KP1_3216(mhpB)
KPM: 
KPP: 
KPK: 
KPH: 
KPZ: 
KPV: 
KPW: 
KPY: 
KPG: 
KPC: 
KPQ: 
KPT: 
KPE: 
KPK_2202(mhpB)
KPO: 
KPR: 
KPR_2666(mhpB)
KPJ: 
KPI: 
KPA: 
KPS: 
KPX: 
KPB: 
KPNE: 
KPNU: 
KVA: 
KVD: 
KVQ: 
KOX: 
KOX_22690(mhpB)
KOE: 
KOY: 
KOK: 
KOM: 
KQU: 
CFD: 
CIF: 
EBT: 
ROR: 
PGE: 
EBF: 
SERR: 
SFW: 
SOD: 
PLU: 
PAY: 
PAU_02353(mhpB)
PTT: 
VEJ: 
VFU: 
PPW: 
PPUH: 
PSV: 
PPSY: 
AVN: 
AVL: 
AVD: 
ACX: 
AEI: 
RPJ: 
REU: 
CNC: 
CBW: 
BVI: 
BVE: 
AK36_3499(mhpB)
BCEW: 
DM40_5003(mhpB)
BMK: 
BCON: 
BGE: 
BUK: 
BXE: 
BXB: 
DR64_4660(mhpB)
BPH: 
BCAI: 
PPNO: 
PPNM: 
PRB: 
PSPU: 
PAPI: 
PVE: 
PFG: 
BPA: 
BBR: 
BBH: 
BBX: 
AXO: 
AXN: 
AXS: 
AFA: 
DAC: 
DEL: 
VPE: 
AZO: 
azo1975(mhpB)
DAR: 
XAU: 
HMC: 
RHZ: 
SPHP: 
SWI: 
MPA: 
MAP_0695(mhpB)
MAO: 
MAVI: 
MAVU: 
MAV: 
MAVD: 
MAVR: 
MAVA: 
MIT: 
MIR: 
MIA: 
MIE: 
MID: 
MYO: 
MSM: 
MSG: 
MSB: 
MSN: 
MSH: 
MSA: 
MUL: 
MUL_0347(mhpB)
MVA: 
MGI: 
MSP: 
MAB: 
MAY: 
MABO: 
MAZ: 
MMC: 
MKM: 
MJL: 
MJD: 
MMI: 
MMAR_4776(mhpB)
MRH: 
MMM: 
W7S_03595(mhpB)
MCB: 
MKN: 
MKS: 
MKI: 
MYV: 
MYE: 
MGO: 
MFT: 
MPHL: 
MVQ: 
MYVA_4047(mhpB) MYVA_4677(pydA)
ASD: 
AS9A_0167(mhpB)
CDR: 
CAZ: 
CII: 
CMV: 
NNO: 
RHA: 
REB: 
ROP: 
ROA: 
REQ: 
RPY: 
RAV: 
SCB: 
SCAB_2101(mhpB)
SVL: 
SRC: 
STRF: 
PSIM: 
FRE: 
FRI: 
NML: 
AMD: 
AMED_5706(mhpB)
AMN: 
RAM_29140(mhpB)
AMM: 
AMES_5632(mhpB)
AMZ: 
B737_5632(mhpB)
AMQ: 
AMETH_1850(mhpB) AMETH_2409(mhpB) AMETH_4604(mhpB)
PDX: 
AFS: 
AFR_23715(mhpB)
 » show all
Taxonomy
Reference
1  [PMID:5881653]
  Authors
Dagley S, Chapman PJ, Gibson DT.
  Title
The metabolism of beta-phenylpropionic acid by an Achromobacter.
  Journal
Biochem. J. 97 (1965) 643-50.
Reference
2
  Authors
Lam, W. W. Y and Bugg, T. D. H.
  Title
Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage.
  Journal
J. Chem. Soc., Chem. Commun. 10 (1994) 1163-1164.
Reference
3  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J. Bacteriol. 180 (1998) 2915-23.
  Sequence
[eco:b0348]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
105503-63-7

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