KEGG   ENZYME: 1.13.11.17Help
Entry
EC 1.13.11.17               Enzyme                                 

Name
indole 2,3-dioxygenase;
indole oxidase;
indoleamine 2,3-dioxygenase (ambiguous);
indole:O2 oxidoreductase;
indole-oxygen 2,3-oxidoreductase (decyclizing);
IDO (ambiguous);
indole:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
indole:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
indole + O2 = 2-formylaminobenzaldehyde [RN:R02338]
Reaction(KEGG)
Substrate
indole [CPD:C00463];
O2 [CPD:C00007]
Product
2-formylaminobenzaldehyde [CPD:C03574]
Comment
Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product.
History
EC 1.13.11.17 created 1972, modified 1986
Pathway
Tryptophan metabolism
Reference
1  [PMID:14170321]
  Authors
NAIR PM, VAIDYANATHAN CS.
  Title
AN INDOLE OXIDASE ISOLATED FROM THE LEAVES OF TECOMA STANS.
  Journal
Biochim. Biophys. Acta. 81 (1964) 496-506.
Reference
2  [PMID:697856]
  Authors
Chauhan YS, Rathore VS, Garg GK, Bhargava A
  Title
Detection of an indole oxidizing system in maize leaves.
  Journal
Biochem. Biophys. Res. Commun. 83 (1978) 1237-45.
Reference
3
  Authors
Divakar, N.G., Subramanian, V., Sugumaran, M. and Vaidyanathan, C.S.
  Title
Indole oxygenase from the leaves of Jasminum grandiflorum.
  Journal
Plant Sci. Lett. 15 (1979) 177-181.
Reference
4  [PMID:16662784]
  Authors
Kunapuli SP, Vaidyanathan CS.
  Title
Purification and Characterization of a New Indole Oxygenase from the Leaves of Tecoma stans L.
  Journal
Plant. Physiol. 71 (1983) 19-23.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-57-8

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