KEGG   ENZYME: 1.13.11.26Help
Entry
EC 1.13.11.26               Enzyme                                 

Name
peptide-tryptophan 2,3-dioxygenase;
pyrrolooxygenase;
peptidyltryptophan 2,3-dioxygenase;
tryptophan pyrrolooxygenase;
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine [RN:R04032]
Reaction(KEGG)
Substrate
[protein]-L-tryptophan;
O2 [CPD:C00007]
Product
[protein]-N-formyl-L-kynurenine
Comment
Also acts on tryptophan.
History
EC 1.13.11.26 created 1972, modified 2011
Reference
1  [PMID:4403729]
  Authors
Frydman RB, Tomaro ML, Frydman B.
  Title
Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides.
  Journal
Biochim. Biophys. Acta. 284 (1972) 80-9.
Reference
2  [PMID:3699018]
  Authors
Camoretti-Mercado B, Frydman RB
  Title
Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of  their substrate specificities using tryptophyl-containing peptides and proteins.
  Journal
Eur. J. Biochem. 156 (1986) 317-25.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-64-7

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