| Entry |
|
| Name |
peptide-tryptophan 2,3-dioxygenase;
pyrrolooxygenase;
peptidyltryptophan 2,3-dioxygenase;
tryptophan pyrrolooxygenase
|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2;
With incorporation of two atoms of oxygen
 |
| Sysname |
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
|
| Reaction(IUBMB) |
[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine [RN: R04032]
|
| Reaction(KEGG) |
|
| Substrate |
[protein]-L-tryptophan;
O2 [CPD: C00007]
|
| Product |
[protein]-N-formyl-L-kynurenine
|
| Comment |
Also acts on tryptophan.
|
| Reference |
|
| Authors |
Frydman RB, Tomaro ML, Frydman B. |
| Title |
Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides. |
| Journal |
Biochim. Biophys. Acta. 284 (1972) 80-9. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Camoretti-Mercado B, Frydman RB |
| Title |
Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins. |
| Journal |
Eur. J. Biochem. 156 (1986) 317-25. |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37256-64-7 |