KEGG   ENZYME: 1.13.11.28Help
Entry
EC 1.13.11.28               Enzyme                                 

Name
2,3-dihydroxybenzoate 2,3-dioxygenase;
2,3-dihydroxybenzoate 2,3-oxygenase;
2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate [RN:R01506]
Reaction(KEGG)
Substrate
2,3-dihydroxybenzoate [CPD:C00196];
O2 [CPD:C00007]
Product
2-carboxy-cis,cis-muconate [CPD:C03666]
Comment
Also acts, more slowly, with 2,3-dihydroxy-4-methylbenzoate and 2,3-dihydroxy-4-isopropylbenzoate.
History
EC 1.13.11.28 created 1978
Reference
1  [PMID:13295279]
  Authors
LA DU BN, ZANNONI VG
  Title
The tyrosine oxidation system of liver. III. Further studies on the oxidation of  p-hydroxyphenylpyruvic acid.
  Journal
J. Biol. Chem. 219 (1956) 273-81.
Reference
2  [PMID:1175620]
  Authors
Sharma HK, Vaidyanathan CS.
  Title
A new mode of ring cleavage of 2,3-dihydroxybenzoic acid in Tecoma stans (L.). Partial purification and properties of 2,3-dihydroxybenzoate 2,3-oxygenase.
  Journal
Eur. J. Biochem. 56 (1975) 163-71.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56802-97-2

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