KEGG   ENZYME: 1.13.11.46Help
Entry
EC 1.13.11.46               Enzyme                                 

Name
4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
Reaction(IUBMB)
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN:R06632]
Reaction(KEGG)
R06632;
(other) R05778
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Substrate
4-hydroxyphenylpyruvate [CPD:C01179];
O2 [CPD:C00007]
Product
(S)-4-hydroxymandelate [CPD:C03198];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
History
EC 1.13.11.46 created 2001
Pathway
Monobactam biosynthesis
Biosynthesis of vancomycin group antibiotics
Biosynthesis of antibiotics
Orthology
K16421  
4-hydroxymandelate synthase
Genes
MSD: 
AGE: 
SCO: 
SCO3229(SCE63.04)
SVL: 
SBH: 
SRC: 
SALU: 
SALL: 
SLV: 
SVT: 
STRE: 
STRC: 
SAMB: 
SRW: 
SPAV: 
SLC: 
STSI: 
SNR: 
SPLU: 
KSK: 
KFL: 
SRO: 
NOA: 
FRA: 
AOI: 
AORI_1495(hppD)
AJA: 
ALU: 
AMI: 
KAL: 
ACTI: 
ACAD: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
CAI: 
HAU: 
 » show all
Taxonomy
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem. Biol. 7 (2000) 931-42.
  Sequence
Reference
2
  Authors
Choroba, O.W., Williams, D.H. and Spencer, J.B.
  Title
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.
  Journal
J. Am. Chem. Soc. 122 (2000) 5389-5390.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
280566-04-3

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