KEGG   ENZYME: 1.13.11.50Help
Entry
EC 1.13.11.50               Enzyme                                 
Name
acetylacetone-cleaving enzyme;
Dke1;
acetylacetone dioxygenase;
diketone cleaving dioxygenase;
diketone cleaving enzyme
Class
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2;
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
acetylacetone:oxygen oxidoreductase
Reaction(IUBMB)
pentane-2,4-dione + O2 = acetate + methylglyoxal [RN:R07183]
Reaction(KEGG)
Substrate
pentane-2,4-dione [CPD:C15499];
O2 [CPD:C00007]
Product
acetate [CPD:C00033];
methylglyoxal [CPD:C00546]
Comment
An Fe(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.
Reference
1  [PMID:12379146]
  Authors
Straganz GD, Glieder A, Brecker L, Ribbons DW, Steiner W.
  Title
Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii.
  Journal
Biochem. J. 369 (2003) 573-81.
  Organism
Acinetobacter johnsonii
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
524047-53-8
DBGET integrated database retrieval system