KEGG   ENZYME: 1.13.11.59Help
Entry
EC 1.13.11.59               Enzyme                                 

Name
torulene dioxygenase;
CAO-2;
CarT
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
torulene:oxygen oxidoreductase
Reaction(IUBMB)
torulene + O2 = 4'-apo-beta,psi-caroten-4'-al + 3-methylbut-2-enal [RN:R09782]
Reaction(KEGG)
Substrate
torulene [CPD:C08613];
O2 [CPD:C00007]
Product
4'-apo-beta,psi-caroten-4'-al [CPD:C19892];
3-methylbut-2-enal [CPD:C07330]
Comment
It is assumed that 3-methylbut-2-enal is formed. The enzyme cannot cleave the saturated 3',4'-bond of gamma-carotene which implies that a 3',4'-double bond is neccessary for this reaction.
History
EC 1.13.11.59 created 2011
Pathway
Carotenoid biosynthesis
Metabolic pathways
Orthology
K17842  
torulene dioxygenase
Genes
CCP: 
YLI: 
NCR: 
NCU11424(cao-2)
NTE: 
NEUTE1DRAFT147619(NEUTE1DRAFT_147619)
SMP: 
PAN: 
TTT: 
MGR: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
ANI: 
AFM: 
AOR: 
AOR_1_1272144(AO090023000740) AOR_1_624164(AO090001000359)
ANG: 
ANI_1_1676184(An04g02710)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
TML: 
SHS: 
ADL: 
GTR: 
MPR: 
MRR: 
ABP: 
AGABI1DRAFT80273(AGABI1DRAFT_80273)
ABV: 
AGABI2DRAFT207832(AGABI2DRAFT_207832)
CPUT: 
SLA: 
ACAN: 
 » show all
Taxonomy
Reference
1  [PMID:17493127]
  Authors
Prado-Cabrero A, Estrada AF, Al-Babili S, Avalos J
  Title
Identification and biochemical characterization of a novel carotenoid oxygenase:  elucidation of the cleavage step in the Fusarium carotenoid pathway.
  Journal
Mol. Microbiol. 64 (2007) 448-60.
  Sequence
Reference
2  [PMID:17610084]
  Authors
Saelices L, Youssar L, Holdermann I, Al-Babili S, Avalos J
  Title
Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway.
  Journal
Mol. Genet. Genomics. 278 (2007) 527-37.
Reference
3  [PMID:18812228]
  Authors
Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S
  Title
Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation.
  Journal
Fungal. Genet. Biol. 45 (2008) 1497-505.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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