KEGG   ENZYME: 1.13.11.62Help
Entry
EC 1.13.11.62               Enzyme                                 

Name
linoleate 10R-lipoxygenase;
10R-DOX;
(10R)-dioxygenase;
10R-dioxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen (10R)-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [RN:R09811]
Reaction(KEGG)
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [CPD:C19937]
Comment
The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.
History
EC 1.13.11.62 created 2011
Pathway
Linoleic acid metabolism
Orthology
K17862  
linoleate 10R-lipoxygenase
Genes
NHE: 
ANI: 
AFM: 
AOR: 
AOR_1_1372154(AO090003000772) AOR_1_988024(AO090010000591)
ANG: 
ANI_1_1118024(An02g07930)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
AJE: 
 » show all
Taxonomy
Reference
1  [PMID:19289462]
  Authors
Garscha U, Oliw EH
  Title
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase  with epoxyalcohol synthase activity.
  Journal
J. Biol. Chem. 284 (2009) 13755-65.
  Sequence
Reference
2  [PMID:20045744]
  Authors
Jerneren F, Garscha U, Hoffmann I, Hamberg M, Oliw EH
  Title
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.
  Journal
Biochim. Biophys. Acta. 1801 (2010) 503-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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