KEGG   ENZYME: 1.13.11.67Help
Entry
EC 1.13.11.67               Enzyme                                 

Name
8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase;
8'-apo-beta-carotenol:O2 oxidoreductase (14',13'-cleaving)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
8'-apo-beta-carotenol:oxygen oxidoreductase (14',13'-cleaving)
Reaction(IUBMB)
8'-apo-beta-carotenol + O2 = 14'-apo-beta-carotenal + an uncharacterized product
Reaction(KEGG)
(other) R08889
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Substrate
8'-apo-beta-carotenol [CPD:C06733];
O2 [CPD:C00007]
Product
14'-apo-beta-carotenal [CPD:C06734];
uncharacterized product
Comment
A thiol-dependent enzyme isolated from rat and rabbit. Unlike EC 1.13.11.63, beta-carotene-15,15'-dioxygenase, it is not active towards beta-carotene. The secondary product has not been characterized, but may be (3E,5E)-7-hydroxy-6-methylhepta-3,5-dien-2-one.
History
EC 1.13.11.67 created 2000 as EC 1.13.12.12, transferred 2012 to EC 1.13.11.67
Reference
1  [PMID:9331970]
  Authors
Dmitrovskii AA, Gessler NN, Gomboeva SB, Ershov YuV, Bykhovsky VYa.
  Title
Enzymatic oxidation of beta-apo-8'-carotenol to beta-apo-14'-carotenal by an enzyme different from beta-carotene-15,15'-dioxygenase.
  Journal
Biochemistry. (Mosc). 62 (1997) 787-92.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
198028-39-6

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