KEGG   ENZYME: 1.13.11.69Help
Entry
EC 1.13.11.69               Enzyme                                 

Name
carlactone synthase;
CCD8 (gene name);
MAX4 (gene name);
NCED8 (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
9-cis-10'-apo-beta-carotenal:oxygen oxidoreductase (14,15-cleaving, carlactone-forming)
Reaction(IUBMB)
9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal [RN:R10558]
Reaction(KEGG)
Substrate
9-cis-10'-apo-beta-carotenal [CPD:C20692];
O2 [CPD:C00007]
Product
carlactone [CPD:C20693];
(2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal [CPD:C20694]
Comment
Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza. Also catalyses EC 1.13.11.70, all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase, but 10-fold slower.
History
EC 1.13.11.69 created 2012
Pathway
Carotenoid biosynthesis
Orthology
K17913  
carlactone synthase / all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase
Genes
ATH: 
AT4G32810(CCD8)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0335089.1(Lj0g3v0335089.1) Lj1g3v2068760.1(Lj1g3v2068760.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
103488182(CCD8)
RCU: 
JCU: 
105638200(CCD8)
POP: 
POPTR_0006s25490g(POPTRDRAFT_561749) POPTR_0018s08010g(POPTRDRAFT_910575)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os01t0566500-01(Os01g0566500) Os01t0746400-00(Os01g0746400)
OBR: 
BDI: 
SBI: 
SORBI_03g034400(SORBIDRAFT_03g034400) SORBI_05g000380(SORBIDRAFT_05g000380) SORBI_05g009950(SORBIDRAFT_05g009950) SORBI_07g024250(SORBIDRAFT_07g024250)
ZMA: 
100502522(CCD8)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
AAF: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:12815068]
  Authors
Sorefan K, Booker J, Haurogne K, Goussot M, Bainbridge K, Foo E, Chatfield S, Ward S, Beveridge C, Rameau C, Leyser O
  Title
MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea.
  Journal
Genes. Dev. 17 (2003) 1469-74.
  Sequence
[ath:AT4G32810]
Reference
2  [PMID:15342640]
  Authors
Schwartz SH, Qin X, Loewen MC
  Title
The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching.
  Journal
J. Biol. Chem. 279 (2004) 46940-5.
  Sequence
[ath:AT4G32810]
Reference
3  [PMID:22422982]
  Authors
Alder A, Jamil M, Marzorati M, Bruno M, Vermathen M, Bigler P, Ghisla S, Bouwmeester H, Beyer P, Al-Babili S
  Title
The path from beta-carotene to carlactone, a strigolactone-like plant hormone.
  Journal
Science. 335 (2012) 1348-51.
  Sequence
[ath:AT4G32810] [osa:4326177]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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