KEGG   ENZYME: 1.13.11.71Help
Entry
EC 1.13.11.71               Enzyme                                 

Name
carotenoid-9',10'-cleaving dioxygenase;
BCO2 (gene name);
beta-carotene 9',10'-monooxygenase (misleading);
all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
all-trans-beta-carotene:oxygen oxidoreductase (9',10'-cleaving)
Reaction(IUBMB)
all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone [RN:R10559]
Reaction(KEGG)
Substrate
all-trans-beta-carotene [CPD:C02094];
O2 [CPD:C00007]
Product
all-trans-10'-apo-beta-carotenal [CPD:C20695];
beta-ionone [CPD:C12287]
Comment
Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.
History
EC 1.13.11.71 created 2012
Orthology
K10252  
beta,beta-carotene 9',10'-dioxygenase
Genes
HSA: 
83875(BCO2)
PTR: 
451548(BCO2)
PPS: 
100968503(BCO2)
GGO: 
PON: 
100434189(BCO2)
NLE: 
100585752(BCO2)
MCC: 
712095(BCO2)
MCF: 
102136772(BCO2)
CSAB: 
103248467(BCO2)
RRO: 
CJC: 
100397428(BCO2)
SBQ: 
101053395(BCO2)
MMU: 
170752(Bco2)
RNO: 
315644(Bco2)
CGE: 
100774947(Bco2)
NGI: 
103733876(Bco2)
HGL: 
101704023(Bco2)
OCU: 
100344631(BCO2)
TUP: 
102485450(BCO2)
CFA: 
479437(BCO2)
AML: 
100482102(SDHD)
UMR: 
103662381(SDHD)
FCA: 
101095765(BCO2)
BTA: 
514135(BCO2)
BOM: 
102280946(BCO2)
PHD: 
102335122(BCO2)
CHX: 
102176146(BCO2)
SSC: 
100517547(BCO2)
CFR: 
102520302(BCO2)
BACU: 
103012517(BCO2)
LVE: 
103086674(BCO2)
ECB: 
100070518(BCO2)
MYB: 
102262734(BCO2)
MYD: 
102751608(PTS) 102756952(BCO2)
PALE: 
102884496(BCO2)
MDO: 
100032246(BCO2)
SHR: 
100919673(BCO2)
OAA: 
100087018(BCO2)
GGA: 
419792(BCO2)
MGP: 
100549031(BCO2)
CJO: 
107324119(BCO2)
APLA: 
101802069(BCO2)
TGU: 
GFR: 
102041586(BCO2)
FAB: 
101819010(BCO2)
PHI: 
102105953(BCO2)
CCW: 
104692076(BCO2)
FPG: 
101911275(BCO2)
FCH: 
102054794(BCO2)
CLV: 
102093604(BCO2)
AAM: 
106495924(BCO2)
ASN: 
102369219(BCO2)
AMJ: 
102569970(BCO2)
PSS: 
102463932(BCO2)
CMY: 
102946859(BCO2)
ACS: 
100568148(bco2)
PBI: 
103051556(BCO2)
GJA: 
107116138(BCO2)
XLA: 
446869(bco2.L)
XTR: 
DRE: 
678554(bco2b) 793849(bco2a)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102356793(BCO2)
CMK: 
103190786(bco2)
BFO: 
SKO: 
ISC: 
NVE: 
ADF: 
SMIN: 
v1.2.036047.t1(symbB.v1.2.036047.t1)
 » show all
Taxonomy
Reference
1  [PMID:11278918]
  Authors
Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J
  Title
Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A.
  Journal
J. Biol. Chem. 276 (2001) 14110-6.
  Sequence
[mmu:170752]
Reference
2  [PMID:15983114]
  Authors
Lindqvist A, He YG, Andersson S
  Title
Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues.
  Journal
J. Histochem. Cytochem. 53 (2005) 1403-12.
  Sequence
[hsa:83875]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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