KEGG   ENZYME: 1.13.11.78Help
Entry
EC 1.13.11.78               Enzyme                                 

Name
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming);
phnZ (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Reaction(IUBMB)
(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate [RN:R10722]
Reaction(KEGG)
Substrate
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
O2 [CPD:C00007]
Product
glycine [CPD:C00037];
phosphate [CPD:C00009]
Comment
Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.
History
EC 1.13.11.78 created 2014
Pathway
Phosphonate and phosphinate metabolism
Orthology
K21196  
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Genes
BFO: 
SPU: 
SKO: 
LGI: 
OBI: 
NVE: 
MAW: 
MAJ: 
CMT: 
AOR: 
ANG: 
ANI_1_2760024(An02g08160)
AFV: 
NFI: 
PCS: 
ZTR: 
PFJ: 
BCOM: 
MRR: 
MBR: 
SRE: 
ACAN: 
SMIN: 
v1.2.002470.t1(symbB.v1.2.002470.t1)
EHX: 
PALC: 
PPG: 
PPT: 
PPUH: 
PPUN: 
PPUD: 
PMON: 
PMOT: 
PMOS: 
PPJ: 
PFL: 
PPRC: 
PPRO: 
PFO: 
PFS: 
PFC: 
PFN: 
PFW: 
PFF: 
PPZ: 
PMAN: 
PTV: 
PEN: 
PBA: 
PPUU: 
PSV: 
PSK: 
PCH: 
PCZ: 
PCP: 
PFZ: 
PSEM: 
PSEC: 
PPSY: 
PSOS: 
PKR: 
PRR: 
LHA: 
CVI: 
CVC: 
MGO: 
NBR: 
NSR: 
PIR: 
CPI: 
NKO: 
PCM: 
MUP: 
CMR: 
CAMU: 
SLI: 
SRD: 
SMON: 
RSI: 
EOL: 
FAE: 
 » show all
Taxonomy
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J. Am. Chem. Soc. 134 (2012) 8364-7.
Reference
2  [PMID:24198335]
  Authors
Worsdorfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME
  Title
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 18874-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system