KEGG   ENZYME: 1.13.12.18Help
Entry
EC 1.13.12.18               Enzyme                                 

Name
dinoflagellate luciferase;
(dinoflagellate luciferin) luciferase;
Gonyaulax luciferase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
dinoflagellate-luciferin:oxygen 132-oxidoreductase
Reaction(IUBMB)
dinoflagellate luciferin + O2 = oxidized dinoflagellate luciferin + H2O + hnu [RN:R09571]
Reaction(KEGG)
Substrate
dinoflagellate luciferin [CPD:C19704];
O2 [CPD:C00007]
Product
oxidized dinoflagellate luciferin [CPD:C19705];
H2O [CPD:C00001];
hnu [CPD:C00205]
Comment
A luciferase from dinoflagelates such as Gonyaulax polyedra, Lingulodinium polyedrum, Noctiluca scintillans, and Pyrocystis lunula. It is a single protein with three luciferase domains. The luciferin is strongly bound by a luciferin binding protein above a pH of 7.
History
EC 1.13.12.18 created 2011
Reference
1  [PMID:7197271]
  Authors
Dunlap JC, Hastings JW
  Title
The biological clock in Gonyaulax controls luciferase activity by regulating turnover.
  Journal
J. Biol. Chem. 256 (1981) 10509-18.
  Sequence
[up:O77206]
Reference
2  [PMID:2745419]
  Authors
Morse D, Pappenheimer AM Jr, Hastings JW
  Title
Role of a luciferin-binding protein in the circadian bioluminescent reaction of Gonyaulax polyedra.
  Journal
J. Biol. Chem. 264 (1989) 11822-6.
Reference
3  [PMID:7918642]
  Authors
Bae YM, Hastings JW
  Title
Cloning, sequencing and expression of dinoflagellate luciferase DNA from a marine alga, Gonyaulax polyedra.
  Journal
Biochim. Biophys. Acta. 1219 (1994) 449-56.
  Sequence
[up:O77206]
Reference
4  [PMID:10812605]
  Authors
Li L
  Title
Gonyaulax luciferase: gene structure, protein expression, and purification from recombinant sources.
  Journal
Methods. Enzymol. 305 (2000) 249-58.
Reference
5  [PMID:10812606]
  Authors
Morse D, Mittag M
  Title
Dinoflagellate luciferin-binding protein.
  Journal
Methods. Enzymol. 305 (2000) 258-76.
Reference
6  [PMID:15665092]
  Authors
Schultz LW, Liu L, Cegielski M, Hastings JW
  Title
Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1378-83.
  Sequence
[up:O77206]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
303183-71-3

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