KEGG   ENZYME: 1.13.12.2Help
Entry
EC 1.13.12.2                Enzyme                                 

Name
lysine 2-monooxygenase;
lysine oxygenase;
lysine monooxygenase;
L-lysine-2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
L-lysine:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-lysine + O2 = 5-aminopentanamide + CO2 + H2O [RN:R00449]
Reaction(KEGG)
Substrate
L-lysine [CPD:C00047];
O2 [CPD:C00007]
Product
5-aminopentanamide [CPD:C00990];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts on other diamino acids.
History
EC 1.13.12.2 created 1972
Pathway
Lysine degradation
Reference
1  [PMID:4624115]
  Authors
Nakazawa T, Hori K, Hayaishi O.
  Title
Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase.
  Journal
J. Biol. Chem. 247 (1972) 3439-44.
Reference
2  [PMID:5911646]
  Authors
Takeda H, Hayaishi O.
  Title
Crystalline L-lysine oxygenase.
  Journal
J. Biol. Chem. 241 (1966) 2733-6.
Reference
3  [PMID:5772467]
  Authors
Takeda H, Yamamoto S, Kojima Y, Hayaishi O.
  Title
Studies on monooxygenases. I. General properties of crystalline L-lysine monooxygenase.
  Journal
J. Biol. Chem. 244 (1969) 2935-41.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-22-5

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