KEGG   ENZYME: 1.13.12.21Help
Entry
EC 1.13.12.21               Enzyme                                 

Name
tetracenomycin-F1 monooxygenase;
tcmH (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
tetracenomycin-F1:oxygen C5-monooxygenase
Reaction(IUBMB)
tetracenomycin F1 + O2 = tetracenomycin D3 + H2O [RN:R06700]
Reaction(KEGG)
Substrate
tetracenomycin F1 [CPD:C12367];
O2 [CPD:C00007]
Product
tetracenomycin D3 [CPD:C12368];
H2O [CPD:C00001]
Comment
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
History
EC 1.13.12.21 created 2013
Pathway
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K15969  
tetracenomycin F1 monooxygenase
Genes
SGU: 
Taxonomy
Reference
1  [PMID:8329392]
  Authors
Shen B, Hutchinson CR.
  Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry. 32 (1993) 6656-63.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system