KEGG   ENZYME: 1.13.12.3Help
Entry
EC 1.13.12.3                Enzyme                                 

Name
tryptophan 2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O [RN:R00679]
Reaction(KEGG)
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
(indol-3-yl)acetamide [CPD:C02693];
CO2 [CPD:C00011];
H2O [CPD:C00001]
History
EC 1.13.12.3 created 1972
Pathway
Tryptophan metabolism
Orthology
K00466  
tryptophan 2-monooxygenase
Genes
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Atu6011(tms1)
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Avi_8288(tms1)
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SCO1454(SCL6.11c)
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Taxonomy
Reference
1  [PMID:5916389]
  Authors
Kosuge T, Heskett MG, Wilson EE.
  Title
Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi.
  Journal
J. Biol. Chem. 241 (1966) 3738-44.
  Organism
Pseudomonas savastanoi
Reference
2
  Authors
Kuo, T.T. and Kosuge, T.
  Title
Factors influencing the production and further metabolism of indole-3-acetic acid by Pseudomonas savastanoi.
  Journal
J. Gen. Appl. Microbiol. 15 (1969) 51-63.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-65-8

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