KEGG   ENZYME: 1.13.99.3Help
Entry
EC 1.13.99.3                Enzyme                                 

Name
tryptophan 2'-dioxygenase;
indole-3-alkane alpha-hydroxylase;
tryptophan side-chain alpha,beta-oxidase;
tryptophan side chain oxidase II;
tryptophan side-chain oxidase;
TSO;
indolyl-3-alkan alpha-hydroxylase;
tryptophan side chain oxidase type I;
TSO I ;
TSO II;
tryptophan side chain oxidase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
Miscellaneous
BRITE hierarchy
Sysname
L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
Reaction(IUBMB)
L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3 [RN:R00681]
Reaction(KEGG)
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
(indol-3-yl)glycolaldehyde [CPD:C03230];
CO2 [CPD:C00011];
NH3 [CPD:C00014]
Comment
A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.
History
EC 1.13.99.3 created 1984
Pathway
Tryptophan metabolism
Reference
1  [PMID:15994]
  Authors
Roberts J, Rosenfeld HJ.
  Title
Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme.
  Journal
J. Biol. Chem. 252 (1977) 2640-7.
Reference
2  [PMID:15995]
  Authors
Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T.
  Title
Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives.
  Journal
J. Biol. Chem. 252 (1977) 2648-56.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
64295-81-4

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