KEGG   ENZYME: 1.14.11.10Help
Entry
EC 1.14.11.10               Enzyme                                 

Name
pyrimidine-deoxynucleoside 1'-dioxygenase;
deoxyuridine-uridine 1'-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)
Reaction(IUBMB)
2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + 2-deoxyribonolactone + succinate + CO2 [RN:R02486]
Reaction(KEGG)
Substrate
2'-deoxyuridine [CPD:C00526];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
uracil [CPD:C00106];
2-deoxyribonolactone [CPD:C02674];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe(II) and ascorbate. cf. EC 1.14.11.3, pyrimidine-deoxynucleoside 2'-dioxygenase.
History
EC 1.14.11.10 created 1989, modified 2002
Reference
1  [PMID:4040518]
  Authors
Stubbe J.
  Title
Identification of two alpha-ketoglutarate-dependent dioxygenases in extracts of Rhodotorula glutinis catalyzing deoxyuridine hydroxylation.
  Journal
J. Biol. Chem. 260 (1985) 9972-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
98865-52-2

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