KEGG   ENZYME: 1.14.11.11Help
Entry
EC 1.14.11.11               Enzyme                                 

Name
hyoscyamine (6S)-dioxygenase;
hyoscyamine 6beta-hydroxylase;
hyoscyamine 6beta-dioxygenase;
hyoscyamine 6-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase [(6S)-hydroxylating]
Reaction(IUBMB)
L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2 [RN:R03812]
Reaction(KEGG)
Substrate
L-hyoscyamine [CPD:C02046];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(6S)-hydroxyhyoscyamine [CPD:C03325];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.11 created 1989
Pathway
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K12692  
hyoscyamine (6S)-dioxygenase
Reference
1  [PMID:16664866]
  Authors
Hashimoto T, Yamada Y.
  Title
Hyoscyamine 6beta-Hydroxylase, a 2-Oxoglutarate-Dependent Dioxygenase, in Alkaloid-Producing Root Cultures.
  Journal
Plant. Physiol. 81 (1986) 619-625.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
103865-33-4

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