| Entry |
|
|---|
| Name |
hyoscyamine (6S)-dioxygenase;
hyoscyamine 6beta-hydroxylase;
hyoscyamine 6beta-dioxygenase;
hyoscyamine 6-hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of
oxygen into each donor
 |
|---|
| Sysname |
L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase
((6S)-hydroxylating) |
|---|
| Reaction(IUBMB) |
L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine +
succinate + CO2 [RN:R03812] |
|---|
| Reaction(KEGG) |
R03812
 |
|---|
| Substrate |
L-hyoscyamine [CPD:C02046];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007] |
|---|
| Product |
(6S)-hydroxyhyoscyamine [CPD:C03325];
succinate [CPD:C00042];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Iron [CPD:C00023];
Ascorbate [CPD:C00072] |
|---|
| Comment |
Requires Fe2+ and ascorbate. |
|---|
| Pathway |
PATH: ec00960 Tropane, piperidine and pyridine alkaloid
biosynthesis
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K12692 hyoscyamine (6S)-dioxygenase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:16664866]
Hashimoto T, Yamada Y.
Hyoscyamine 6beta-Hydroxylase, a 2-Oxoglutarate-Dependent
Dioxygenase, in Alkaloid-Producing Root Cultures.
Plant. Physiol. 81 (1986) 619-625.
Atropa belladonna, Datura fastuosa, Duboisia leichhardtii,
Hyoscyamus albus, Hyoscyamus gyorffi, Hyoscyamus muticus, Hyoscyamus
niger, Hyoscyamus pusillus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.11.11
IUBMB Enzyme Nomenclature: 1.14.11.11
ExPASy - ENZYME nomenclature database: 1.14.11.11
BRENDA, the Enzyme Database: 1.14.11.11
CAS: 103865-33-4 |
|---|
