KEGG   ENZYME: 1.14.11.14Help
Entry
EC 1.14.11.14               Enzyme                                 

Name
6beta-hydroxyhyoscyamine epoxidase;
hydroxyhyoscyamine dioxygenase;
(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
(6S)-6beta-hydroxyhyoscyamine,2-oxoglutarate:oxygen oxidoreductase (epoxide-forming)
Reaction(IUBMB)
(6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2 + H2O [RN:R03737]
Reaction(KEGG)
Substrate
(6S)-6beta-hydroxyhyoscyamine;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
scopolamine [CPD:C01851];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.14 created 1992
Pathway
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1
  Authors
Hashimoto, T., Kohno, J. and Yamada, Y.
  Title
6beta-Hydroxyhyoscyamine epoxidase from cultured roots of Hyoscyamus niger.
  Journal
Phytochemistry 28 (1989) 1077-1082.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
121479-53-6

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