KEGG   ENZYME: 1.14.11.22Help
Entry
EC 1.14.11.22               Enzyme                                 

Name
flavone synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating)
Reaction(IUBMB)
a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O [RN:R07367]
Reaction(KEGG)
Substrate
flavanone [CPD:C00766];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
flavone [CPD:C10043];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
Requires ascorbate for full activity and Fe2+.
History
EC 1.14.11.22 created 2004
Pathway
Flavonoid biosynthesis
Isoflavonoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13077  
flavone synthase
Reference
1  [PMID:11524111]
  Authors
Martens S, Forkmann G, Matern U, Lukacin R.
  Title
Cloning of parsley flavone synthase I.
  Journal
Phytochemistry. 58 (2001) 43-6.
  Sequence
Reference
2  [PMID:11516175]
  Authors
Lukacin R, Matern U, Junghanns KT, Heskamp ML, Britsch L, Forkmann G, Martens S.
  Title
Purification and antigenicity of flavone synthase I from irradiated parsley cells.
  Journal
Arch. Biochem. Biophys. 393 (2001) 177-83.
Reference
3  [PMID:12782296]
  Authors
Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R.
  Title
Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley.
  Journal
FEBS. Lett. 544 (2003) 93-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
138263-98-6

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