KEGG   ENZYME: 1.14.11.36Help
Entry
EC 1.14.11.36               Enzyme                                 

Name
pentalenolactone F synthase;
penD (gene name);
pntD (gene name);
ptlD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
pentalenolactone D + 2 2-oxoglutarate + 2 O2 = pentalenolactone F + 2 succinate + 2 CO2 + H2O (overall reaction) [RN:R10145];
(1a) pentalenolactone D + 2-oxoglutarate + O2 = pentalenolactone E + succinate + CO2 + H2O [RN:R10143];
(1b) pentalenolactone E + 2-oxoglutarate + O2 = pentalenolactone F + succinate + CO2 [RN:R10144]
Reaction(KEGG)
Substrate
pentalenolactone D [CPD:C20399];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
pentalenolactone E [CPD:C20398]
Product
pentalenolactone F [CPD:C20397];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001];
pentalenolactone E [CPD:C20398]
Comment
Requires Fe(II) and ascorbate. Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis. Part of the pentalenolactone biosynthesis pathway.
History
EC 1.14.11.36 created 2012
Pathway
Biosynthesis of antibiotics
Orthology
K18057  
pentalenolactone F synthase
Genes
SMA: 
SAV_2995(ptlD)
SBH: 
SCI: 
SCW: 
Taxonomy
Reference
1  [PMID:21250661]
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final  steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry. 50 (2011) 1739-54.
  Sequence
[sma:SAV_2995]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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