KEGG   ENZYME: 1.14.11.38Help
Entry
EC 1.14.11.38               Enzyme                                 

Name
verruculogen synthase;
fmtF (gene name);
FmtOx1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
fumitremorgin B,2-oxoglutarate:oxygen oxidoreductase (verruculogen-forming)
Reaction(IUBMB)
fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 = verruculogen + succinate + CO2 + H2O + A [RN:R10445]
Reaction(KEGG)
Substrate
fumitremorgin B [CPD:C20630];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
AH2 [CPD:C00030]
Product
verruculogen [CPD:C20045];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001];
A [CPD:C00028]
Comment
Requires Fe2+ and ascorbate. Found in the fungus Aspergillus fumigatus. Both atoms of a dioxygen molecule are incorporated into verruculogen [1,2]. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A.
History
EC 1.14.11.38 created 2013
Orthology
K17825  
verruculogen synthase
Genes
AFM: 
NFI: 
URE: 
Taxonomy
Reference
1  [PMID:19763315]
  Authors
Steffan N, Grundmann A, Afiyatullov S, Ruan H, Li SM
  Title
FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus.
  Journal
Org. Biomol. Chem. 7 (2009) 4082-7.
  Organism
Aspergillus fumigatus
  Sequence
Reference
2  [PMID:21404415]
  Authors
Kato N, Suzuki H, Takagi H, Uramoto M, Takahashi S, Osada H
  Title
Gene disruption and biochemical characterization of verruculogen synthase of Aspergillus fumigatus.
  Journal
Chembiochem. 12 (2011) 711-4.
  Organism
Aspergillus fumigatus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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