KEGG   ENZYME: 1.14.11.46Help
Entry
EC 1.14.11.46               Enzyme                                 

Name
2-aminoethylphosphonate dioxygenase;
phnY (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
(2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2 [RN:R10724]
Reaction(KEGG)
Substrate
(2-aminoethyl)phosphonate [CPD:C03557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2-amino-1-hydroxyethyl)phosphonate;
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway.
History
EC 1.14.11.46 created 2014
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J. Am. Chem. Soc. 134 (2012) 8364-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system