KEGG   ENZYME: 1.14.11.9Help
Entry
EC 1.14.11.9                Enzyme                                 

Name
flavanone 3-dioxygenase;
naringenin 3-hydroxylase;
flavanone 3-hydroxylase;
flavanone 3beta-hydroxylase;
flavanone synthase I;
(2S)-flavanone 3-hydroxylase;
naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
a flavanone + 2-oxoglutarate + O2 = a dihydroflavonol + succinate + CO2 [RN:R07329]
Reaction(KEGG)
Substrate
flavanone [CPD:C00766];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
dihydroflavonol [CPD:C15570];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.9 created 1983, modified 1989, modified 2004
Pathway
Flavonoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00475  
naringenin 3-dioxygenase
Genes
ATH: 
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NNU: 
DOSA: 
Os04t0662600-00(Os04g0662600)
OBR: 
BDI: 
SBI: 
SORBI_06g031790(SORBIDRAFT_06g031790)
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 » show all
Taxonomy
Reference
1
  Authors
Forkmann, G., Heller, W. and Grisebach, H.
  Title
Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3- and flavonoid 3'-hydroxylases.
  Journal
Z. Naturforsch. C: Biosci. 35 (1980) 691-695.
Reference
2  [PMID:15013767]
  Authors
Wellmann F, Matern U, Lukacin R.
  Title
Significance of C-terminal sequence elements for Petunia flavanone 3beta-hydroxylase activity.
  Journal
FEBS. Lett. 561 (2004) 149-54.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
75991-43-4

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