KEGG   ENZYME: 1.14.12.1Help
Entry
EC 1.14.12.1                Enzyme                                 

Name
anthranilate 1,2-dioxygenase (deaminating, decarboxylating);
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
Reaction(IUBMB)
anthranilate + NAD(P)H + 2 H+ + O2 = catechol + CO2 + NAD(P)+ + NH3 [RN:R00823 R00825]
Reaction(KEGG)
Substrate
anthranilate [CPD:C00108];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
CO2 [CPD:C00011];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
NH3 [CPD:C00014]
Comment
Requires Fe2+.
History
EC 1.14.12.1 created 1972
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K05599  anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit
K05600  anthranilate 1,2-dioxygenase (deaminating, decarboxylating) small subunit
K16319  anthranilate 1,2-dioxygenase large subunit
K16320  anthranilate 1,2-dioxygenase small subunit
Genes
EBT: EBL_c12070 EBL_c12080
SFO: Z042_01300 Z042_01305
PSD: DSC_14475 DSC_14480 DSC_14600 DSC_14605 DSC_14835 DSC_14840
PAE: PA2512(antA) PA2513(antB)
PAEV: N297_2583(antA) N297_2584(antB)
PAEI: N296_2583(antA) N296_2584(antB)
PAU: PA14_32150(antB) PA14_32160(antA)
PAP: PSPA7_2724(antB) PSPA7_2725(antA)
PAG: PLES_27821(antB) PLES_27831(antA)
PAF: PAM18_2526(antB) PAM18_2527(antA)
PNC: NCGM2_3517(antA) NCGM2_3518(antB)
PAEB: NCGM1900_4014(antB) NCGM1900_4015(antA)
PAEU: BN889_02736(antA) BN889_02737(antB)
PAEC: M802_2580(antA) M802_2581(antB)
PAEO: M801_2448(antA) M801_2449(antB)
PRE: PCA10_14970(antB) PCA10_14980(antA) PCA10_p0060(antB) PCA10_p0070(antA)
PCQ: PcP3B5_23610(antB) PcP3B5_23620(antA_1)
PFL: PFL_0758(antB) PFL_0759(antA)
PPRC: PFLCHA0_c07680(xylY1) PFLCHA0_c07690(xylX1)
PPRO: PPC_0771(antB) PPC_0772(antA)
PFC: PflA506_4487(antA) PflA506_4488(antB)
PMAN: OU5_1638(tpaAa) OU5_1639
PKC: PKB_2111(antB) PKB_2112(antA) PKB_3279(andac1) PKB_3280 PKB_3628(andac3) PKB_3629
PSES: PSCI_5126 PSCI_5127(antB)
PSOS: POS17_0747(antB) POS17_0748(antA)
ABM: ABSDF1970(antB) ABSDF1971(antA)
ABY: ABAYE1896(antA) ABAYE1897(antB)
ABB: ABBFA_001746(antA) ABBFA_001747(antB)
ABAD: ABD1_17400(antB) ABD1_17410(antA)
ACC: BDGL_001117(antB) BDGL_001118(antA)
ACI: ACIAD2669(antA) ACIAD2670(antB)
HBE: BEI_0566(antA) BEI_0567
PSE: NH8B_0399(antB) NH8B_0400(antA)
REH: H16_B0800(h16_B0800) H16_B0801(h16_B0801)
BGU: KS03_3803(antA) KS03_3804(antB)
BUK: MYA_3862
AXX: ERS451415_02888(andAd_2) ERS451415_02889(andAc_2)
HSE: Hsero_3663(nagH) Hsero_3664(nagG)
CARE: LT85_0141(ohbA) LT85_0142(ohbB)
THK: CCZ27_09675(antB) CCZ27_09680(antA)
SPHD: HY78_22210
SJP: SJA_C1-25220(andAc) SJA_C1-25230(andAd)
NFR: ERS450000_00309(andAc)
RHA: RHA1_ro08176(tpaAa) RHA1_ro08177(tpaAb) RHA1_ro10198(tpaAb) RHA1_ro10199(tpaAa)
PDX: Psed_0075
ACTI: UA75_12805
ACAD: UA74_12725
AHG: AHOG_12000(andAd)
 » show all
Taxonomy
Reference
1
  Authors
Kobayashi, S. and Hayaishi, O.
  Title
Anthranilic acid conversion to catechol (Pseudomonas).
  Journal
Methods Enzymol. 17A (1970) 505-510.
Reference
2  [PMID:14209949]
  Authors
TANIUCHI H, HATANAKA M, KUNO S, HAYAISHI O, NAKAJIMA M, KURIHARA N.
  Title
ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID.
  Journal
J. Biol. Chem. 239 (1964) 2204-11.
Other DBs
ExplorEnz - The Enzyme Database: 1.14.12.1
IUBMB Enzyme Nomenclature: 1.14.12.1
ExPASy - ENZYME nomenclature database: 1.14.12.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.1
BRENDA, the Enzyme Database: 1.14.12.1
CAS: 9059-17-0

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