| Entry |
|
|---|
| Name |
anthranilate 1,2-dioxygenase (deaminating, decarboxylating);
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of two atoms of
oxygen into the other donor
 |
|---|
| Sysname |
anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating,
deaminating, decarboxylating) |
|---|
| Reaction(IUBMB) |
anthranilate + NAD(P)H + 2 H+ + O2 = catechol + CO2 + NAD(P)+ + NH3
[RN:R00823 R00825] |
|---|
| Reaction(KEGG) |
R00823 R00825
 |
|---|
| Substrate |
anthranilate [CPD:C00108];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
catechol [CPD:C00090];
CO2 [CPD:C00011];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
NH3 [CPD:C00014] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
Requires Fe2+. |
|---|
| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00629 Carbazole degradation
PATH: ec00910 Nitrogen metabolism |
|---|
| Orthology |
KO: K05599 anthranilate 1,2-dioxygenase (deaminating,
decarboxylating) large subunit
KO: K05600 anthranilate 1,2-dioxygenase (deaminating,
decarboxylating) small subunit |
|---|
| Genes |
PAE: PA2512(antA) PA2513(antB)
PAU: PA14_32150(antB) PA14_32160(antA)
PAP: PSPA7_2724(antB) PSPA7_2725(antA)
PAG: PLES_27821(antB) PLES_27831(antA)
PFL: PFL_0758 PFL_0759
ACI: ACIAD2669(antA) ACIAD2670(antB)
ABM: ABSDF1970(antB) ABSDF1971(antA)
ABY: ABAYE1896(antA) ABAYE1897(antB)
ABC: ACICU_01784 ACICU_01785
ABN: AB57_1977(antB) AB57_1978(antA)
ABB: ABBFA_001746(antA) ABBFA_001747(antB)
 |
|---|
Reference
Authors
Title
Journal
|
1
Kobayashi, S. and Hayaishi, O.
Anthranilic acid conversion to catechol (Pseudomonas).
Methods Enzymol. 17A (1970) 505-510. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14209949]
TANIUCHI H, HATANAKA M, KUNO S, HAYAISHI O, NAKAJIMA M, KURIHARA N.
ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID.
J. Biol. Chem. 239 (1964) 2204-11.
Pseudomonas fluorescens, Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.12.1
IUBMB Enzyme Nomenclature: 1.14.12.1
ExPASy - ENZYME nomenclature database: 1.14.12.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.1
BRENDA, the Enzyme Database: 1.14.12.1
CAS: 9059-17-0 |
|---|
