KEGG   ENZYME: 1.14.12.1Help
Entry
EC 1.14.12.1                Enzyme                                 

Name
anthranilate 1,2-dioxygenase (deaminating, decarboxylating);
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
Reaction(IUBMB)
anthranilate + NAD(P)H + 2 H+ + O2 = catechol + CO2 + NAD(P)+ + NH3 [RN:R00823 R00825]
Reaction(KEGG)
Substrate
anthranilate [CPD:C00108];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
CO2 [CPD:C00011];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
NH3 [CPD:C00014]
Comment
Requires Fe2+.
History
EC 1.14.12.1 created 1972
Pathway
Aminobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K05599  
anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit
K05600  
anthranilate 1,2-dioxygenase (deaminating, decarboxylating) small subunit
K16319  
anthranilate 1,2-dioxygenase large subunit
K16320  
anthranilate 1,2-dioxygenase small subunit
Genes
EBT: 
PLU: 
SFO: 
PSD: 
PAE: 
PA2512(antA) PA2513(antB)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PFL: 
PFL_0758(antB) PFL_0759(antA)
PPRC: 
PFS: 
PFC: 
PRE: 
ACI: 
ACIAD2669(antA) ACIAD2670(antB)
ACD: 
ABM: 
ABSDF1970(antB) ABSDF1971(antA)
ABY: 
ABAYE1896(antA) ABAYE1897(antB)
ABC: 
ABN: 
AB57_1977(antB) AB57_1978(antA)
ABB: 
ABX: 
ABZ: 
ABR: 
ABD: 
ABH: 
ABAD: 
ABJ: 
ABAB: 
ABAJ: 
ABAZ: 
ACC: 
ALT: 
TTU: 
CYQ: 
CZA: 
MMW: 
MME: 
MPC: 
PSE: 
NH8B_0399(antB) NH8B_0400(antA)
RSO: 
RSc1089(nagH) RSc1090(nagG)
RSL: 
RSN: 
RSM: 
RSE: 
F504_1060(ohbA) F504_1061(ohbB)
REU: 
REH: 
RME: 
Rmet_3712(nagH)
CNC: 
BMA: 
BMV: 
BML: 
BMN: 
BPS: 
BPM: 
BPL: 
BPD: 
BPR: 
BPSE: 
BPZ: 
BPQ: 
BPK: 
BTE: 
BTD: 
BVI: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BAM: 
BAC: 
BMU: 
BMJ: 
BMULJ_03557(andAc) BMULJ_03558(andAd)
BCT: 
BXE: 
BGL: 
BUG: 
BGE: 
BGD: 
BYI: 
BUK: 
BPX: 
BUO: 
PPK: 
PRB: 
BPE: 
BPC: 
BPER: 
BPA: 
BPAR: 
BBR: 
BBM: 
BBH: 
BPT: 
BAV: 
AXY: 
AXO: 
AXN: 
AKA: 
POL: 
PNA: 
AAV: 
AJS: 
AAA: 
ACK: 
VEI: 
VAP: 
VPE: 
VPD: 
RTA: 
HSE: 
LCH: 
AZO: 
azo2515(nagH) azo2516(nagG)
SUR: 
MSL: 
PHL: 
NAR: 
NPP: 
SWI: 
SJP: 
AZL: 
ALI: 
TMO: 
MVA: 
MGI: 
MSP: 
MMC: 
MKM: 
MJL: 
MRH: 
RHA: 
AAU: 
PDX: 
 » show all
Taxonomy
Reference
1
  Authors
Kobayashi, S. and Hayaishi, O.
  Title
Anthranilic acid conversion to catechol (Pseudomonas).
  Journal
Methods Enzymol. 17A (1970) 505-510.
Reference
2  [PMID:14209949]
  Authors
TANIUCHI H, HATANAKA M, KUNO S, HAYAISHI O, NAKAJIMA M, KURIHARA N.
  Title
ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID.
  Journal
J. Biol. Chem. 239 (1964) 2204-11.
  Organism
Pseudomonas fluorescens, Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9059-17-0

DBGET integrated database retrieval system