KEGG   ENZYME: 1.14.12.1Help
Entry
EC 1.14.12.1                Enzyme                                 
Name
anthranilate 1,2-dioxygenase (deaminating, decarboxylating);
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
Reaction(IUBMB)
anthranilate + NAD(P)H + 2 H+ + O2 = catechol + CO2 + NAD(P)+ + NH3 [RN:R00823 R00825]
Reaction(KEGG)
Substrate
anthranilate [CPD:C00108];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
CO2 [CPD:C00011];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
NH3 [CPD:C00014]
Comment
Requires Fe2+.
Pathway
Aminobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K05599  
anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit
K05600  
anthranilate 1,2-dioxygenase (deaminating, decarboxylating) small subunit
K16319  
anthranilate 1,2-dioxygenase large subunit
K16320  
anthranilate 1,2-dioxygenase small subunit
Genes
EBT: 
PLU: 
PSD: 
PAE: 
PA2512(antA) PA2513(antB)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PFL: 
PFL_0758(antB) PFL_0759(antA)
PFS: 
PFLU5194 PFLU5195
PFC: 
PflA506_4487(antA) PflA506_4488(antB)
ACI: 
ACIAD2669(antA) ACIAD2670(antB)
ACD: 
AOLE_09970 AOLE_09975
ABM: 
ABSDF1970(antB) ABSDF1971(antA)
ABY: 
ABAYE1896(antA) ABAYE1897(antB)
ABC: 
ACICU_01784 ACICU_01785
ABN: 
AB57_1977(antB) AB57_1978(antA)
ABB: 
ABBFA_001746(antA) ABBFA_001747(antB)
ABX: 
ABK1_2243 ABK1_2244
ABZ: 
ABZJ_01953 ABZJ_01954
ABR: 
ABTJ_01921 ABTJ_01922
ABD: 
ABTW07_1997 ABTW07_1998
ABH: 
M3Q_2137 M3Q_2138
ACC: 
BDGL_001117(antB) BDGL_001118(antA)
ALT: 
ambt_18005 ambt_18010
TTU: 
TERTU_1474 TERTU_1475
CYQ: 
Q91_0876 Q91_0964(andAc) Q91_0966 Q91_1469 Q91_2196 Q91_2230 Q91_2231
MMW: 
Mmwyl1_2669 Mmwyl1_2670
MME: 
Marme_2404 Marme_2405
MPC: 
Mar181_2357 Mar181_2358
PSE: 
NH8B_0399(antB) NH8B_0400(antA)
RSO: 
RSc1089(nagH) RSc1090(nagG)
RSL: 
RPSI07_2301 RPSI07_2302
RSN: 
RSPO_c02274 RSPO_c02275(nagH)
REU: 
Reut_B3776 Reut_B4719 Reut_B4720
REH: 
H16_A1632(nagH) H16_A1633(nagG) H16_B0801
RME: 
Rmet_3712(nagH)
CNC: 
CNE_1c16400(nagH) CNE_1c16410(nagG) CNE_2c07490(bphA) CNE_BB1p12630(hcaE) CNE_BB1p12640
BMA: 
BMAA0203 BMAA0204
BMV: 
BMASAVP1_1378 BMASAVP1_1379
BML: 
BMA10229_1575 BMA10229_1576
BMN: 
BMA10247_A0234 BMA10247_A0235
BPS: 
BPSS1887 BPSS1888
BPM: 
BURPS1710b_A0982 BURPS1710b_A0983
BPL: 
BURPS1106A_A2562 BURPS1106A_A2563
BPD: 
BURPS668_A2706 BURPS668_A2707
BPR: 
GBP346_A0961 GBP346_A0962
BPZ: 
BP1026B_II2026 BP1026B_II2027
BPQ: 
BPC006_II2524 BPC006_II2525
BTE: 
BTH_II0488 BTH_II0489
BVI: 
Bcep1808_4162 Bcep1808_4163
BUR: 
Bcep18194_B2324 Bcep18194_B2325
BCN: 
Bcen_4587 Bcen_4588
BCH: 
Bcen2424_3775 Bcen2424_3776
BCM: 
Bcenmc03_3747 Bcenmc03_3748
BCJ: 
BCAM0810 BCAM0811
BAM: 
Bamb_5502 Bamb_5503
BAC: 
BamMC406_3667 BamMC406_3668
BMU: 
Bmul_4956 Bmul_4957
BMJ: 
BMULJ_03557(andAc) BMULJ_03558(andAd)
BCT: 
GEM_4989 GEM_4990
BXE: 
Bxe_A1101 Bxe_A1102 Bxe_A1107(ohbB) Bxe_A1108(ohbA) Bxe_B1108 Bxe_B1109 Bxe_B2751 Bxe_B2752 Bxe_C0942 Bxe_C1121(andAc)
BGL: 
bglu_2g20110 bglu_2g20120 bglu_2g21220 bglu_2g21230
BUG: 
BC1001_0576 BC1001_0577 BC1001_2081 BC1001_2082
BGE: 
BC1002_7006 BC1002_7007
BGD: 
bgla_2g22320 bgla_2g22330
BYI: 
BYI23_D006360 BYI23_D010460(tphA) BYI23_D010470
BUK: 
MYA_3862
BPX: 
BUPH_04466 BUPH_04467
BPE: 
BP0584
BPC: 
BPTD_0593
BPER: 
BN118_3483
BPA: 
BPP0274 BPP2193
BPAR: 
BN117_0272 BN117_1352
BBR: 
BB0277 BB1590 BB1591
BBM: 
BN115_0262 BN115_1544 BN115_1545
BBH: 
BN112_1865 BN112_1866 BN112_3140
BPT: 
Bpet1540 Bpet1541 Bpet2804 Bpet2805
BAV: 
BAV0657 BAV0658 BAV1583
AXY: 
AXYL_00938 AXYL_00939 AXYL_02469 AXYL_03917 AXYL_03918 AXYL_06581(bphA) AXYL_06586 AXYL_06587
AKA: 
TKWG_00630
POL: 
Bpro_0983 Bpro_0984
PNA: 
Pnap_2487 Pnap_2488
AAV: 
Aave_0165 Aave_0166
AJS: 
Ajs_3090
AAA: 
Acav_0196 Acav_0197
ACK: 
C380_09995 C380_10000
VEI: 
Veis_4604 Veis_4605
VAP: 
Vapar_4290 Vapar_5348 Vapar_5349
VPE: 
Varpa_2933 Varpa_2934
CTT: 
CtCNB1_1493 CtCNB1_1494
RTA: 
Rta_16740 Rta_16750 Rta_25980 Rta_25990
HSE: 
Hsero_3663(nagH) Hsero_3664(nagG)
LCH: 
Lcho_0796 Lcho_0797
AZO: 
azo2515(nagH) azo2516(nagG)
SUR: 
STAUR_1173(ohbA)
MSL: 
Msil_1468 Msil_1469
PHL: 
KKY_2640 KKY_2641
NAR: 
Saro_3860 Saro_3867 Saro_3868
NPP: 
PP1Y_AT15578 PP1Y_AT15588 PP1Y_AT15646 PP1Y_AT15862 PP1Y_AT31639 PP1Y_AT31702 PP1Y_AT31705
SWI: 
Swit_3056 Swit_3057
SJP: 
SJA_C1-25220(andAc) SJA_C1-25230(andAd)
AZL: 
AZL_a06710 AZL_a06720 AZL_a09200 AZL_a09210
ALI: 
AZOLI_p11024 AZOLI_p11025 AZOLI_p20648 AZOLI_p20649
TMO: 
TMO_a0553 TMO_a0554(bphA)
MVA: 
Mvan_0493
MGI: 
Mflv_0562 Mflv_0657
MSP: 
Mspyr1_01670
MMC: 
Mmcs_1647
MKM: 
Mkms_1673 Mkms_5631
MJL: 
Mjls_1622 Mjls_2232
MRH: 
MycrhN_3163 MycrhN_3164
RHA: 
RHA1_ro08176(tpaAa) RHA1_ro08177(tpaAb) RHA1_ro10198(tpaAb) RHA1_ro10199(tpaAa)
AAU: 
AAur_pTC10252 AAur_pTC10253
PDX: 
Psed_0075
 » show all
Taxonomy
Reference
1
  Authors
Kobayashi, S. and Hayaishi, O.
  Title
Anthranilic acid conversion to catechol (Pseudomonas).
  Journal
Methods Enzymol. 17A (1970) 505-510.
Reference
2  [PMID:14209949]
  Authors
TANIUCHI H, HATANAKA M, KUNO S, HAYAISHI O, NAKAJIMA M, KURIHARA N.
  Title
ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID.
  Journal
J. Biol. Chem. 239 (1964) 2204-11.
  Organism
Pseudomonas fluorescens, Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9059-17-0
DBGET integrated database retrieval system