KEGG   ENZYME: 1.14.12.15Help
Entry
EC 1.14.12.15               Enzyme                                 

Name
terephthalate 1,2-dioxygenase;
benzene-1,4-dicarboxylate 1,2-dioxygenase;
1,4-dicarboxybenzoate 1,2-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)
Reaction(IUBMB)
terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ [RN:R05148]
Reaction(KEGG)
Substrate
terephthalate [CPD:C06337];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate [CPD:C06318];
NAD+ [CPD:C00003]
Comment
Has been shown to contain a Rieske [2Fe-2S] cluster
History
EC 1.14.12.15 created 1999
Pathway
Polycyclic aromatic hydrocarbon degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K18074  
terephthalate 1,2-dioxygenase oxygenase component alpha subunit
K18075  
terephthalate 1,2-dioxygenase oxygenase component beta subunit
Genes
VPD: 
CTT: 
CTES: 
RTA: 
Taxonomy
Reference
1  [PMID:7961417]
  Authors
Schlafli HR, Weiss MA, Leisinger T, Cook AM.
  Title
Terephthalate 1,2-dioxygenase system from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.
  Journal
J. Bacteriol. 176 (1994) 6644-52.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
162032-76-0

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